TMEM14A - transmembrane protein 14A Gene

Also Known as PTD011; C6orf73

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28978

Summary

Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in brain (RPKM 28.6), adrenal (RPKM 23.3) and 25 other tissues.

TMEM14A Products (1)

mRNA Protein Name
NM_014051.4 NP_054770.1 transmembrane protein 14A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21723035 GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21723035 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21723035 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
21723035 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM14A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM14A Q9Y6G1 LXN Homo sapiens Q9BS40
Y2H Array
25416956
Intra
TMEM14A Q9Y6G1 LXN Homo sapiens Q9BS40
Y2H Prey Pooling
25416956
Intra
TMEM14A Q9Y6G1 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 LRCH1 Homo sapiens Q9Y2L9-3
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 LRCH1 Homo sapiens Q9Y2L9-3
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 CXCR3 Homo sapiens P49682
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 ERMAP Homo sapiens Q96PL5
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 ERMAP Homo sapiens Q96PL5
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 SLC19A3 Homo sapiens Q9BZV2
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SLC19A3 Homo sapiens Q9BZV2
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 IER3IP1 Homo sapiens Q9Y5U9
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 IER3IP1 Homo sapiens Q9Y5U9
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TMEM14A Q9Y6G1 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TMEM14A Q9Y6G1 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171333 TMEM16A modulator-1 Modulator 99.86% Unkown
HY-RS14668 TMEM140 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14669 TMEM145 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14670 TMEM147 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14671 TMEM14C Human Pre-designed siRNA Set A Pre-designed Set / Unkown