TMEM74 - transmembrane protein 74 Gene

Also Known as NET36

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 157753

About TMEM74

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,606,850-108,787,594 (from NCBI)

This gene has 2 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in brain (RPKM 1.7), heart (RPKM 0.4) and 6 other tissues.

Summary

Involved in macroautophagy. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM74 Products (1)

mRNA Protein Name
NM_153015.3 NP_694560.1 transmembrane protein 74

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
18294959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM74 Protein Structure

Neurensin

Neurensin: Neurensin (175 - 258)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

transmembrane protein 74

TMEM74 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM74 Q96NL1 TMEM42 Homo sapiens Q69YG0
Y2H Prey Pooling
32296183
Intra
TMEM74 Q96NL1 TMEM42 Homo sapiens Q69YG0
Y2H Array
32296183
Intra
TMEM74 Q96NL1 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM74 Q96NL1 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM74 Q96NL1 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
TMEM74 Q96NL1 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
TMEM74 Q96NL1 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
TMEM74 Q96NL1 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
TMEM74 Q96NL1 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14741 TMEM74 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMEM74 MGD MGI:2443417
Macaca mulatta TMEM74 VGNC VGNC:79606
Felis catus TMEM74 VGNC VGNC:66362
Rattus norvegicus TMEM74 RGD RGD:1566279
Canis familiaris TMEM74 VGNC VGNC:47604
Bos taurus TMEM74 VGNC VGNC:36111
Others TMEM74 NCBI