FRMD8 - FERM domain containing 8 Gene

Also Known as iTAP; FKSG44

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83786

About FRMD8

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,368,026-65,426,526 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 9.9), skin (RPKM 9.0) and 25 other tissues.

Summary

Involved in positive regulation of tumor necrosis factor production. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FRMD8 Products (3)

mRNA Protein Name
NM_001300832.3 NP_001287761.1 FERM domain-containing protein 8 isoform 2
NM_001300833.3 NP_001287762.1 FERM domain-containing protein 8 isoform 3
NM_031904.5 NP_114110.1 FERM domain-containing protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
29897333 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
29897336 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
29897333 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
29897333 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMD8 Protein Structure

FERM_M

FERM_M: FERM central domain (139 - 272)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

FERM domain-containing protein 8

  • band4.1 inhibitor LRP interactor

FRMD8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FRMD8 Q9BZ67 KCNH2 Homo sapiens Q12809-2
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 KCNH2 Homo sapiens Q12809-2
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 ZNF474 Homo sapiens Q6S9Z5
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 ZNF474 Homo sapiens Q6S9Z5
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
FRMD8 Q9BZ67 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 GRAMD2B Homo sapiens Q96HH9
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 GRAMD2B Homo sapiens Q96HH9
Y2H Array
25416956
Intra
FRMD8 Q9BZ67 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25416956
Intra
FRMD8 Q9BZ67 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 ZNF446 Homo sapiens Q9NWS9-2
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra
FRMD8 Q9BZ67 ZNF446 Homo sapiens Q9NWS9-2
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
FRMD8 Q9BZ67 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Intra
FRMD8 Q9BZ67 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
FRMD8 Q9BZ67 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
FRMD8 Q9BZ67 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tylosis With Esophageal Cancer

  • Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome

  • TOC

  • Keratosis Palmaris Et Plantaris With Esophageal Cancer

  • Bennion-Patterson Syndrome

  • Howell-Evans Syndrome

  • Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome

  • Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome

  • Tylosis-Oesophageal Carcinoma Syndrome

  • Palmoplantar Keratoderma With Esophageal Cancer

  • Howel-Evans Syndrome

  • Keratosis Palmoplantaris With Esophageal Cancer

  • Tylosis - Oesophageal Carcinoma

  • Howel-Evans' Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05106 FRMD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FRMD8 RGD RGD:1310323
Mus musculus FRMD8 MGD MGI:1914707
Canis familiaris FRMD8 VGNC VGNC:51873
Felis catus FRMD8 VGNC VGNC:102893
Bos taurus FRMD8 VGNC VGNC:56264
Macaca mulatta FRMD8 VGNC VGNC:101087
Others FRMD8 NCBI