CALN1 - calneuron 1 Gene

Also Known as CABP8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83698

About CALN1

Cytogenetic location: 7q11.22 Genomic coordinates (GRCh38): 7:71,779,491-72,504,279 (from NCBI)

This gene has 6 transcripts (splice variants), 277 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.4), adrenal (RPKM 3.0) and 1 other tissue.

Summary

This gene encodes a protein with high similarity to the calcium-binding proteins of the Calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CALN1 Products (3)

mRNA	Protein	Name
NM_001017440.3	NP_001017440.1	calcium-binding protein 8 isoform 2
NM_001363460.1	NP_001350389.1	calcium-binding protein 8 isoform 2
NM_031468.4	NP_113656.2	calcium-binding protein 8 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	19338761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALN1 Protein Structure

EF-hand_7

0
100
200
219 a.a.

Protein Preferred Names	Protein Names
calcium-binding protein 8	calcium-binding protein CABP8

CALN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Array	32296183
Intra	CALN1	Q9BXU9	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
D-Glyceric Aciduria	D-Glyceric Acidemia D-Glycericacidemia Glycerate Kinase Deficiency D-Glycerate Kinase Deficiency Non Ketotic Hyperglycinemia Syndrome Deficiency Of Glycerate Kinase Hyperglycinemia, Non-Ketotic D-GA
Deafness, Autosomal Recessive 39	DFNB39 Autosomal Recessive Nonsyndromic Deafness 39 Autosomal Recessive Deafness 39 Deafness, Autosomal Recessive, 39 Congenital Neurosensory Deafness Autosomal Recessive 39 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39 Deafness, Autosomal Recessive, Type 39
Drug Psychosis	Drug-Induced Psychosis Drug-Induced Psychotic Disorder Psychoses, Substance-Induced Psychoses, Drug
Drug-Induced Mental Disorder
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01846	CALN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CALN1	VGNC	VGNC:82078
Mus musculus	CALN1	MGD	MGI:2155987
Rattus norvegicus	CALN1	RGD	RGD:1305843
Canis familiaris	CALN1	VGNC	VGNC:38674
Bos taurus	CALN1	VGNC	VGNC:26714