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USE1 - unconventional SNARE in the ER 1 Gene

Also Known as D12; P31; SLT1; MDS032

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55850

About USE1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,215,357-17,219,829 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in brain (RPKM 7.1), fat (RPKM 6.8) and 25 other tissues.

Summary

Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

USE1 Products (1)

mRNA	Protein	Name
NM_018467.4	NP_060937.2	vesicle transport protein USE1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15029241	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15029241	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USE1 Protein Structure

Use1

0
100
200
259 a.a.

Protein Preferred Names	Protein Names
vesicle transport protein USE1	Q-SNARE

USE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USE1	Q9NZ43	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	USE1	Q9NZ43	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	USE1	Q9NZ43	CALN1	Homo sapiens	Q9BXU9	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	CALN1	Homo sapiens	Q9BXU9	Y2H Array	32296183
Intra	USE1	Q9NZ43	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	USE1	Q9NZ43	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	USE1	Q9NZ43	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	USE1	Q9NZ43	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	CCM2L	Homo sapiens	Q9NUG4	Y2H Array	32296183
Intra	USE1	Q9NZ43	CCM2L	Homo sapiens	Q9NUG4	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	USE1	Q9NZ43	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	USE1	Q9NZ43	APOL2	Homo sapiens	Q9BQE5	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	APOL2	Homo sapiens	Q9BQE5	Y2H Array	32296183
Intra	USE1	Q9NZ43	CCDC70	Homo sapiens	Q6NSX1	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	CCDC70	Homo sapiens	Q6NSX1	Y2H Array	32296183
Intra	USE1	Q9NZ43	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	USE1	Q9NZ43	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	USE1	Q9NZ43	STX18	Homo sapiens	Q9P2W9	Pull Down	19369418
Intra	USE1	Q9NZ43	STX18	Homo sapiens	Q9P2W9	Anti Bait CoIP	19369418
Intra	USE1	Q9NZ43	STX18	Homo sapiens	Q9P2W9	Anti Tag CoIP	33961781
Intra	USE1	Q9NZ43	STX18	Homo sapiens	Q9P2W9	Anti Tag CoIP	28514442
Intra	USE1	Q9NZ43	STX18	Homo sapiens	Q9P2W9	Anti Tag CoIP	19369418
Intra	USE1	Q9NZ43	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	USE1	Q9NZ43	STX4	Homo sapiens	Q12846	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood Malignant Schwannoma	Pediatric Mpnst Childhood Neurofibrosarcoma
Anteroseptal Myocardial Infarction
Infantile Liver Failure Syndrome	Infantile Liver Failure
Macular Degeneration, Age-Related, 8	Age Related Macular Degeneration 8 ARMD8 Macular Degeneration, Age-Related, Type 8
Vestibulocochlear Nerve Disease	Vestibulocochlear Nerve Diseases Acoustic Nerve Disease Cochlear Nerve Diseases Disturbance Of Vestibulocochlear Nerve Auditory Nerve Disorder Disorder Of Acoustovestibular Nerve Disorder Of Eighth Nerve Eighth Cranial Nerve Disorder Disease Of Eighth Cranial Nerve Disease Of Acoustic Nerve Disease Of Auditory Nerve Disorder Of 8th Cranial Nerve Auditory Nerve Lesion Cochlear Nerve Disorder
Vestibular Neuronitis	Vestibular Neuritis Epidemic Neurolabyrinthitis
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Dysostosis	Dysostoses

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0338R	Ethylene glycol (Standard)		99.81%	Unkown

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126047A	(R,S)-Anatabine		99.67%	Unkown
HY-126047AR	(R,S)-Anatabine (Standard)		97.98%	Unkown
HY-131144S	AMOZ-d5		99.60%	Unkown
HY-135711	PDE8B-IN-1		99.91%	Unkown
HY-D1830	Vari Fluor 680 Carboxylic acid（free acid）		97.0%	Unkown
HY-P1378A	β-Amyloid (1-43)(human) TFA		95.42%	Unkown
HY-D1821	Vari Fluor 750 Carboxylic acid（free acid）		≥95.0%	Unkown
HY-W143890	Etifenin		99.74%	Unkown
HY-117831	NSC-79887	Inhibitor	/	Unkown
HY-126047AS	(R,S)-Anatabine-d4		95.08%	Unkown
HY-131622	7-Aminoclonazepam	Control	/	Unkown
HY-161755	Anticancer agent 232		/	Unkown
HY-D0228	4-(4-Nitrophenylazo)resorcinol		/	Unkown
HY-D1822	Vari Fluor 555 Carboxylic acid（free acid）		96.0%	Unkown
HY-D1823	Vari Fluor 647A Carboxylic acid（free acid）		98.0%	Unkown
HY-D1824	Vari Fluor 488 Carboxylic acid（free acid）		/	Unkown
HY-D1825	Vari Fluor 532 Carboxylic acid（free acid）		95.0%	Unkown
HY-D1826	Vari Fluor 594 Carboxylic acid（free acid）		/	Unkown
HY-D1827	Vari Fluor 660 Carboxylic acid（free acid）		/	Unkown
HY-D1828	Vari Fluor 640 Carboxylic acid（free acid）		/	Unkown
HY-D1829	Vari Fluor 568 Carboxylic acid（free acid）		/	Unkown
HY-P1378	β-Amyloid (1-43)(human)		/	Unkown
HY-RS15367	UBE2Z Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15512	USE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W102356R	Phenethyl acetate (Standard)		/	Unkown
HY-W102356S	Phenethyl acetate-d3		/	Unkown
HY-171739	PLPEth (16:0/18:2 PEth)		/	Unkown
HY-RS19397	Use1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25889	Use1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W102356	Phenethyl acetate		99.27%	Unkown
HY-W102356S1	Phenethyl acetate-13C2		/	Unkown
HY-W102356S2	Phenethyl acetate-d5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USE1	RGD	RGD:1306660
Felis catus	USE1	VGNC	VGNC:66859
Bos taurus	USE1	VGNC	VGNC:107017
Mus musculus	USE1	MGD	MGI:1914273
Macaca mulatta	USE1	VGNC	VGNC:79892
Canis familiaris	USE1	VGNC	VGNC:48171
Others	USE1	NCBI