DCTN5 - dynactin subunit 5 Gene

Homo sapiens

Gene ID: 84516 | Gene type: protein coding

About DCTN5

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,641,466-23,677,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in brain (RPKM 13.0), testis (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

DCTN5 Products(3)

mRNA	Protein	Name
NM_001199011.2	NP_001185940.1	dynactin subunit 5 isoform 2
NM_001199743.2	NP_001186672.1	dynactin subunit 5 isoform 3
NM_032486.4	NP_115875.1	dynactin subunit 5 isoform 1

DCTN5 Protein Structure

Hexapep

0
100
182 a.a.

Protein Preferred Names

Protein Names

dynactin subunit 5

dynactin 4

Related Diseases

Diseases

Alias

Autosomal Dominant Nonsyndromic Deafness 77

Dfna77

Charcot-Marie-Tooth Disease, Axonal, Type 2o

Charcot-Marie-Tooth Disease Axonal Type 2o	CMT2O
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2o	Charcot-Marie-Tooth Neuropathy Axonal Type 2o
Charcot-Marie-Tooth Neuropathy, Axonal, Type 2o	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2o
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2o	Charcot-Marie-Tooth Disease 2o
Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2o

Joubert Syndrome 17

JBTS17

Joubert Syndrome, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03596	DCTN5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCTN5	VGNC	VGNC:61381
Macaca mulatta	DCTN5	VGNC	VGNC:71703
Bos taurus	DCTN5	VGNC	VGNC:27932
Canis familiaris	DCTN5	VGNC	VGNC:39820
Rattus norvegicus	DCTN5	RGD	RGD:1305654
Mus musculus	DCTN5	MGD	MGI:1891689

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