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RNF183 - ring finger protein 183 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 138065

About RNF183

This gene has 7 transcripts (splice variants), 92 orthologues and 3 paralogues. Biased expression in gall bladder (RPKM 1.5), kidney (RPKM 1.3) and 7 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF183 Products (7)

mRNA	Protein	Name
NM_001371234.1	NP_001358163.1	E3 ubiquitin-protein ligase RNF183
NM_001371235.1	NP_001358164.1	E3 ubiquitin-protein ligase RNF183
NM_001371236.1	NP_001358165.1	E3 ubiquitin-protein ligase RNF183
NM_001371237.1	NP_001358166.1	E3 ubiquitin-protein ligase RNF183
NM_001387568.1	NP_001374497.1	E3 ubiquitin-protein ligase RNF183
NM_001387569.1	NP_001374498.1	E3 ubiquitin-protein ligase RNF183
NM_145051.5	NP_659488.2	E3 ubiquitin-protein ligase RNF183

RNF183 Protein Structure

zf-RING_5

0
100
192 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF183	probable E3 ubiquitin-protein ligase RNF183

RNF183 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF183	Q96D59	UBE2W	Homo sapiens	Q96FI0	Y2H Prey Pooling	32296183
Intra	RNF183	Q96D59	UBE2W	Homo sapiens	Q96FI0	Validated Y2H	32296183
Intra	RNF183	Q96D59	UBE2W	Homo sapiens	Q96FI0	Y2H Array	32296183
Intra	RNF183	Q96D59	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RNF183	Q96D59	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RNF183	Q96D59	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RNF183	Q96D59	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	RNF183	Q96D59	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	RNF183	Q96D59	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	RNF183	Q96D59	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RNF183	Q96D59	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RNF183	Q96D59	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RNF183	Q96D59	GOPC	Homo sapiens	Q9HD26-2	Y2H Prey Pooling	32296183
Intra	RNF183	Q96D59	GOPC	Homo sapiens	Q9HD26-2	Validated Y2H	32296183
Intra	RNF183	Q96D59	GOPC	Homo sapiens	Q9HD26-2	Y2H Array	32296183
Intra	RNF183	Q96D59	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	RNF183	Q96D59	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	RNF183	Q96D59	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	RNF183	Q96D59	ERCC8	Homo sapiens	Q13216-2	Validated Y2H	32814053
Intra	RNF183	Q96D59	ERCC8	Homo sapiens	Q13216-2	Y2H Array	32814053
Intra	RNF183	Q96D59	ERCC8	Homo sapiens	Q13216-2	Y2H Pooling	32814053
Intra	RNF183	Q96D59	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	RNF183	Q96D59	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	RNF183	Q96D59	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	RNF183	Q96D59	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	RNF183	Q96D59	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	RNF183	Q96D59	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	RNF183	Q96D59	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	RNF183	Q96D59	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	RNF183	Q96D59	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	RNF183	Q96D59	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Array	32814053
Intra	RNF183	Q96D59	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Pooling	32814053
Intra	RNF183	Q96D59	q9p1n4_human	Homo sapiens	Q9P1N4	Validated Y2H	32814053
Intra	RNF183	Q96D59	TPP1	Homo sapiens	O14773	Validated Y2H	32814053
Intra	RNF183	Q96D59	TPP1	Homo sapiens	O14773	Y2H Array	32814053
Intra	RNF183	Q96D59	TPP1	Homo sapiens	O14773	Y2H Pooling	32814053
Intra	RNF183	Q96D59	GOPC	Homo sapiens	Q9HD26	Validated Y2H	25416956
Intra	RNF183	Q96D59	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	RNF183	Q96D59	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	RNF183	Q96D59	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	RNF183	Q96D59	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	RNF183	Q96D59	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RNF183	Q96D59	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RNF183	Q96D59	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RNF183	Q96D59	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RNF183	Q96D59	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RNF183	Q96D59	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RNF183	Q96D59	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	RNF183	Q96D59	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	RNF183	Q96D59	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	RNF183	Q96D59	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RNF183	Q96D59	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RNF183	Q96D59	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RNF183	Q96D59	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	RNF183	Q96D59	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	RNF183	Q96D59	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	RNF183	Q96D59	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	RNF183	Q96D59	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	RNF183	Q96D59	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	RNF183	Q96D59	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	RNF183	Q96D59	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	RNF183	Q96D59	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	RNF183	Q96D59	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RNF183	Q96D59	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RNF183	Q96D59	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RNF183	Q96D59	TAX1BP3	Homo sapiens	O14907	Validated Y2H	25416956
Intra	RNF183	Q96D59	TAX1BP3	Homo sapiens	O14907	Y2H Prey Pooling	25416956
Intra	RNF183	Q96D59	LITAF	Homo sapiens	Q99732	Validated Y2H	32814053
Intra	RNF183	Q96D59	LITAF	Homo sapiens	Q99732	Y2H Array	32814053
Intra	RNF183	Q96D59	LITAF	Homo sapiens	Q99732	Y2H Pooling	32814053
Intra	RNF183	Q96D59	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	RNF183	Q96D59	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	RNF183	Q96D59	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	RNF183	Q96D59	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	RNF183	Q96D59	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	RNF183	Q96D59	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	RNF183	Q96D59	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	RNF183	Q96D59	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	RNF183	Q96D59	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	RNF183	Q96D59	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	RNF183	Q96D59	DBH	Homo sapiens	P09172	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hemolytic Disease Of Fetus And Newborn, Rh-Induced	Rh Deficiency Syndrome Rh Disease HDFNRH Rh Fetomaternal Incompatibility Rh-Null Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12068	RNF183 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF183	VGNC	VGNC:76855
Felis catus	RNF183	VGNC	VGNC:64685
Rattus norvegicus	RNF183	RGD	RGD:1564412
Bos taurus	RNF183	VGNC	VGNC:34041
Mus musculus	RNF183	MGD	MGI:1923322
Others	RNF183	NCBI