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TUBA1B - tubulin alpha 1b Gene

Also Known as K-ALPHA-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10376

About TUBA1B

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,127,782-49,131,395 (from NCBI)

This gene has 8 transcripts (splice variants), 68 orthologues and 23 paralogues. Ubiquitous expression in brain (RPKM 600.4), bone marrow (RPKM 551.8) and 24 other tissues.

Summary

Enables double-stranded RNA binding activity and ubiquitin protein Ligase binding activity. Predicted to be involved in microtubule Cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]

TUBA1B Products (1)

mRNA	Protein	Name
NM_006082.3	NP_006073.2	tubulin alpha-1B chain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	34996871	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	34996871	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11698390	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	34996871	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21753002	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	34996871	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA
is active in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	34996871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUBA1B Protein Structure

Tubulin

Tubulin_C

0
100
200
300
400
451 a.a.

Protein Preferred Names	Protein Names
tubulin alpha-1B chain	alpha tubulin

TUBA1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TUBA1B	P68363	TUBB3	Homo sapiens	Q13509	Anti Tag CoIP	35271311
Intra	TUBA1B	P68363	TUBB3	Homo sapiens	Q13509	Light Scattering	24021646
Intra	TUBA1B	P68363	TUBB3	Homo sapiens	Q13509	LM	24021646
Intra	TUBA1B	P68363	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	TUBA1B	P68363	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Cross	TUBA1B	P68363	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	18457437

Cross: Cross-species interaction Intra: Intraspecies interaction

TUBA1B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80485	alpha Tubulin (acetyl K40) Antibody (YA626)	WB	Human
HY-P83296	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041)	WB, ICC/IF	Human
HY-P83296A	Phospho-alpha Tubulin (Tyr272) Antibody (YA3041)(PBS only)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Sanjad-Sakati Syndrome Hrd Syndrome HRDS Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome Richardson-Kirk Syndrome Sss Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay Hypoparathyroidism With Short Stature, Mental Retardation And Seizures Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15246	TUBA1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21213	Tuba1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27729	Tuba1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TUBA1B	RGD	RGD:1565476
Mus musculus	TUBA1B	MGD	MGI:107804