TBRG4 - transforming growth factor beta regulator 4 Gene

Also Known as CPR2; FASTKD4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9238

About TBRG4

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:45,100,100-45,111,697 (from NCBI)

This gene has 17 transcripts (splice variants), 195 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 18.2), duodenum (RPKM 14.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

TBRG4 Products (4)

mRNA Protein Name
NM_001261834.2 NP_001248763.1 FAST kinase domain-containing protein 4 isoform 3
NM_004749.4 NP_004740.2 FAST kinase domain-containing protein 4 isoform 1
NM_030900.4 NP_112162.1 FAST kinase domain-containing protein 4 isoform 2
NM_199122.3 NP_954573.1 FAST kinase domain-containing protein 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA metabolic process IMP
IMP: Inferred from mutant phenotype
28335001 GOA
involved in mitochondrial mRNA processing IMP
IMP: Inferred from mutant phenotype
28335001 GOA
involved in regulation of mitochondrial mRNA stability IMP
IMP: Inferred from mutant phenotype
28335001 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
28335001 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
20869947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBRG4 Protein Structure

FAST_1

FAST_1: FAST kinase-like protein, subdomain 1 (369 - 437)

FAST_2

FAST_2: FAST kinase-like protein, subdomain 2 (450 - 536)

RAP

RAP: RAP domain (569 - 620)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 631 a.a.
Protein Preferred Names Protein Names

FAST kinase domain-containing protein 4

  • FAST kinase domains 4

TBRG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TBRG4 Q969Z0 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
TBRG4 Q969Z0 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 TNFRSF10D Homo sapiens Q9UBN6
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 TNFRSF10D Homo sapiens Q9UBN6
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 TNFRSF10D Homo sapiens Q9UBN6
Y2H Array
32296183
Intra
TBRG4 Q969Z0 FAM114A2 Homo sapiens Q9NRY5
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 FAM114A2 Homo sapiens Q9NRY5
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 FAM114A2 Homo sapiens Q9NRY5
Y2H Array
32296183
Intra
TBRG4 Q969Z0 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
TBRG4 Q969Z0 CDR2L Homo sapiens Q86X02
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 CDR2L Homo sapiens Q86X02
Y2H Array
32296183
Intra
TBRG4 Q969Z0 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 TMEM239 Homo sapiens Q8WW34-2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 TMEM239 Homo sapiens Q8WW34-2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 PRB3 Homo sapiens Q04118
Y2H Array
32296183
Intra
TBRG4 Q969Z0 PRB3 Homo sapiens Q04118
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TBRG4 Q969Z0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 CMTM4 Homo sapiens Q8IZR5-2
Y2H Array
32296183
Intra
TBRG4 Q969Z0 CMTM4 Homo sapiens Q8IZR5-2
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
TBRG4 Q969Z0 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
TBRG4 Q969Z0 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
Intra
TBRG4 Q969Z0 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
TBRG4 Q969Z0 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
TBRG4 Q969Z0 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra
TBRG4 Q969Z0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
TBRG4 Q969Z0 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra
TBRG4 Q969Z0 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
TBRG4 Q969Z0 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
TBRG4 Q969Z0 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
TBRG4 Q969Z0 MAL2 Homo sapiens Q969L2
Validated Y2H
25416956
Intra
TBRG4 Q969Z0 MAL2 Homo sapiens Q969L2
Y2H Array
25416956
Intra
TBRG4 Q969Z0 SCAMP1 Homo sapiens O15126
Y2H Array
32296183
Intra
TBRG4 Q969Z0 SCAMP1 Homo sapiens O15126
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14269 TBRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TBRG4 VGNC VGNC:47168
Rattus norvegicus TBRG4 RGD RGD:1309737
Bos taurus TBRG4 VGNC VGNC:35664
Mus musculus TBRG4 MGD MGI:1100868
Felis catus TBRG4 VGNC VGNC:66000
Macaca mulatta TBRG4 VGNC VGNC:78151
Others TBRG4 NCBI