PRB3 - proline rich protein BstNI subfamily 3 Gene

Also Known as G1; PRG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5544

About PRB3

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,265,914-11,269,707 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 4 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 9550.6).

Summary

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of Polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

PRB3 Products (2)

mRNA Protein Name
NM_001394862.1 NP_001381791.1 basic salivary proline-rich protein 3 isoform 2 precursor
NM_006249.5 NP_006240.4 basic salivary proline-rich protein 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRB3 Protein Structure

Pro-rich

Pro-rich: Proline-rich (1 - 136)

Pro-rich

Pro-rich: Proline-rich (109 - 182)

Pro-rich

Pro-rich: Proline-rich (173 - 243)

Pro-rich

Pro-rich: Proline-rich (217 - 304)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

basic salivary proline-rich protein 3

  • BstNI type basic salivary proline-rich protein 3

PRB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRB3 Q04118 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra
PRB3 Q04118 TBRG4 Homo sapiens Q969Z0
Validated Y2H
32296183
Intra
PRB3 Q04118 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra
PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
PRB3 Q04118 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Head And Neck Cancer

  • Head And Neck Neoplasm

  • Head And Neck Tumours

  • Head/Neck Neoplasm

  • Tumor Of Head And Neck

  • Head And Neck Neoplasms

  • Hnc

  • Cancer, Head/Neck
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11053 PRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRB3 RGD RGD:620386