2. Gene
  3. GTF3C1 - general transcription factor IIIC subunit 1 Gene

GTF3C1 - general transcription factor IIIC subunit 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TFIIIC; TFIIIC220; TFIIICalpha

Gene ID: 2975 | Gene type: protein coding

About GTF3C1

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,460,613-27,549,913 (from NCBI)

This gene has 13 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues.

Summary

Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF3C1 Products(2)

mRNA Protein Name
NM_001286242.2 NP_001273171.1 general transcription factor 3C polypeptide 1 isoform 2
NM_001520.4 NP_001511.2 general transcription factor 3C polypeptide 1 isoform 1

GTF3C1 Protein Structure

B-block_TFIIIC

B-block_TFIIIC: B-block binding subunit of TFIIIC (175 - 249)

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  • 2109 a.a.
Protein Preferred Names Protein Names

general transcription factor 3C polypeptide 1

TF3C-alpha

Related Diseases

Diseases Alias
Esophageal Atresia

Tracheoesophageal Fistula

Congenital Atresia Of Esophagus

Congenital Imperforate Esophagus

Imperforate Esophagus

Oesophageal Atresia

Te Fistula

Tef

Tracheoesophageal Fistula With Or Without Esophageal Atresia
Cerebellofaciodental Syndrome

Cerebellar-Facial-Dental Syndrome

CFDS
Esophageal Atresia/Tracheoesophageal Fistula

Esophageal Atresia And/Or Tracheoesophageal Fistula

Tracheoesophageal Fistula With Or Without Esohageal Atresia

Esophageal Atresia / Tracheoesophageal Fistula

Ea/Tef

Esophageal Atresia With Tracheoesophageal Fistula

Esophageal Atresia With Or Without Tracheoesophageal Fistula
Bulbar Polio

Poliomyelitis, Bulbar

Bulbar Poliomyelitis
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1

Smard1

DSMA1

Sianrf

Dhmn6

Spinal Muscular Atrophy With Respiratory Distress 1

HMN6

Severe Infantile Axonal Neuropathy With Respiratory Failure

Autosomal Recessive Distal Spinal Muscular Atrophy 1

Diaphragmatic Spinal Muscular Atrophy

Spinal Muscular Atrophy With Respiratory Distress Type 1

Neuronopathy, Distal Hereditary Motor, Type Vi

Hmn Vi

Neuronopathy, Severe Infantile Axonal, With Respiratory Failure

Distal Spinal Muscular Atrophy 1

Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress

Distal Hereditary Motor Neuropathy Type 6

Distal-Hmn Type 6

Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1

Spinal Muscular Atrophy, Diaphragmatic

Distal Hereditary Motor Neuronopathy Type Vi

Distal Spinal Muscular Atrophy Type 1

Hmnvi

Spinal Muscular Atrophy With Respiratory Distress

Autosomal Recessive Distal Spinal Muscular Atrophy Type 1

Neuronopathy, Distal Hereditary Motor, 6

Dhmn Vi

Distal Hereditary Motor Neuropathy Type Vi

Severe Infantile Axonal Neuronopathy With Respiratory Failure

Spinal Muscular Atrophy Distal Autosomal Recessive 1

Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy

Autosomal Recessive Distal Spinal Muscular Atrophy
Breast Squamous Cell Carcinoma

Breast Primary Squamous Cell Carcinoma

Primary Squamous Cell Carcinoma Of Breast

Primary Squamous Cell Carcinoma Of The Breast

Scc Of Breast

Squamous Cell Carcinoma Of Breast

Squamous Cell Breast Carcinoma
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05906 GTF3C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GTF3C1 MGD MGI:107887
Bos taurus GTF3C1 VGNC VGNC:29702
Rattus norvegicus GTF3C1 RGD RGD:621048
Felis catus GTF3C1 VGNC VGNC:67503
Canis familiaris GTF3C1 VGNC VGNC:41551
Macaca mulatta GTF3C1 VGNC VGNC:73316