NDRG4 - NDRG family member 4 Gene

Also Known as BDM1; SMAP8; SMAP-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65009

About NDRG4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,463,715-58,515,387 (from NCBI)

This gene has 55 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 109.2), heart (RPKM 62.3) and 4 other tissues.

Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

NDRG4 Products (24)

mRNA Protein Name
NM_001130487.2 NP_001123959.1 protein NDRG4 isoform 2
NM_001242833.2 NP_001229762.1 protein NDRG4 isoform 4
NM_001242834.2 NP_001229763.1 protein NDRG4 isoform 5
NM_001242835.2 NP_001229764.1 protein NDRG4 isoform 6
NM_001242836.2 NP_001229765.1 protein NDRG4 isoform 3
NM_001363869.2 NP_001350798.1 protein NDRG4 isoform 7
NM_001378332.1 NP_001365261.1 protein NDRG4 isoform 8
NM_001378333.1 NP_001365262.1 protein NDRG4 isoform 9
NM_001378334.1 NP_001365263.1 protein NDRG4 isoform 10
NM_001378335.1 NP_001365264.1 protein NDRG4 isoform 11
NM_001378336.1 NP_001365265.1 protein NDRG4 isoform 12
NM_001378337.1 NP_001365266.1 protein NDRG4 isoform 13
NM_001378338.1 NP_001365267.1 protein NDRG4 isoform 14
NM_001378339.1 NP_001365268.1 protein NDRG4 isoform 15
NM_001378340.1 NP_001365269.1 protein NDRG4 isoform 15
NM_001378341.1 NP_001365270.1 protein NDRG4 isoform 16
NM_001378342.1 NP_001365271.1 protein NDRG4 isoform 17
NM_001378343.1 NP_001365272.1 protein NDRG4 isoform 18
NM_001378344.1 NP_001365273.1 protein NDRG4 isoform 19
NM_001378345.1 NP_001365274.1 protein NDRG4 isoform 20
NM_001378346.1 NP_001365275.1 protein NDRG4 isoform 1
NM_001378347.1 NP_001365276.1 protein NDRG4 isoform 21
NM_020465.4 NP_065198.1 protein NDRG4 isoform 1
NM_022910.4 NP_075061.1 protein NDRG4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
12755708 GOA
involved in negative regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
12755708 GOA
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
12755708 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
12755708 GOA
Cellular Component GO Annotation Evidence Références Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
19535783 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12755708 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDRG4 Protein Structure

Ndr

Ndr: Ndr family (8 - 289)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

protein NDRG4

  • N-myc downstream-regulated gene 4 protein

NDRG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NDRG4 Q9ULP0 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
Intra
NDRG4 Q9ULP0 RABAC1 Homo sapiens Q9UI14
Y2H Array
25416956
Intra
NDRG4 Q9ULP0 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
Intra
NDRG4 Q9ULP0 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
Intra
NDRG4 Q9ULP0 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Charcot-Marie-Tooth Disease, Type 4d

  • Charcot-Marie-Tooth Disease Type 4d

  • CMT4D

  • Hmsnl

  • Hmsn4d

  • Charcot-Marie-Tooth Neuropathy Type 4d

  • Hereditary Motor And Sensory Neuropathy Lom Type

  • Hmsn-Lom

  • Neuropathy, Hereditary Motor And Sensory, Lom Type

  • Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d

  • Charcot-Marie-Tooth Neuropathy, Type 4d

  • Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d

  • Hmsn Lom Type

  • Hmsn, Lom Type

  • Hereditary Motor And Sensory Neuropathy, Lom Type

  • Charcot-Marie-Tooth Disease 4d

  • Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d

  • Hereditary Motor And Sensory Neuropathy Ivd

  • Hmsn Ivd
Tetralogy Of Fallot

  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Infantile Myofibromatosis

  • Lipofibromatosis

  • Myofibromatosis
Colorectal Adenoma

  • Colorectal Adenomas

  • Adenoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09117 NDRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22674 Ndrg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29188 Ndrg4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NDRG4 VGNC VGNC:31941
Macaca mulatta NDRG4 VGNC VGNC:74955
Canis familiaris NDRG4 VGNC VGNC:43681
Felis catus NDRG4 VGNC VGNC:63755
Mus musculus NDRG4 MGD MGI:2384590
Rattus norvegicus NDRG4 RGD RGD:621593
Others NDRG4 NCBI