NDRG4 - NDRG family member 4 Gene

Homo sapiens

Also known as BDM1; SMAP8; SMAP-8

Gene ID: 65009 | Gene type: protein coding

About NDRG4

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,463,715-58,515,387 (from NCBI)

This gene has 55 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 109.2), heart (RPKM 62.3) and 4 other tissues.

Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

NDRG4 Products(24)

mRNA	Protein	Name
NM_001130487.2	NP_001123959.1	protein NDRG4 isoform 2
NM_001242833.2	NP_001229762.1	protein NDRG4 isoform 4
NM_001242834.2	NP_001229763.1	protein NDRG4 isoform 5
NM_001242835.2	NP_001229764.1	protein NDRG4 isoform 6
NM_001242836.2	NP_001229765.1	protein NDRG4 isoform 3
NM_001363869.2	NP_001350798.1	protein NDRG4 isoform 7
NM_001378332.1	NP_001365261.1	protein NDRG4 isoform 8
NM_001378333.1	NP_001365262.1	protein NDRG4 isoform 9
NM_001378334.1	NP_001365263.1	protein NDRG4 isoform 10
NM_001378335.1	NP_001365264.1	protein NDRG4 isoform 11
NM_001378336.1	NP_001365265.1	protein NDRG4 isoform 12
NM_001378337.1	NP_001365266.1	protein NDRG4 isoform 13
NM_001378338.1	NP_001365267.1	protein NDRG4 isoform 14
NM_001378339.1	NP_001365268.1	protein NDRG4 isoform 15
NM_001378340.1	NP_001365269.1	protein NDRG4 isoform 15
NM_001378341.1	NP_001365270.1	protein NDRG4 isoform 16
NM_001378342.1	NP_001365271.1	protein NDRG4 isoform 17
NM_001378343.1	NP_001365272.1	protein NDRG4 isoform 18
NM_001378344.1	NP_001365273.1	protein NDRG4 isoform 19
NM_001378345.1	NP_001365274.1	protein NDRG4 isoform 20
NM_001378346.1	NP_001365275.1	protein NDRG4 isoform 1
NM_001378347.1	NP_001365276.1	protein NDRG4 isoform 21
NM_020465.4	NP_065198.1	protein NDRG4 isoform 1
NM_022910.4	NP_075061.1	protein NDRG4 isoform 1

NDRG4 Protein Structure

Ndr

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

protein NDRG4

N-myc downstream-regulated gene 4 protein

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Charcot-Marie-Tooth Disease, Type 4d

Charcot-Marie-Tooth Disease Type 4d	CMT4D
Hmsnl	Hmsn4d
Charcot-Marie-Tooth Neuropathy Type 4d	Hereditary Motor And Sensory Neuropathy Lom Type
Hmsn-Lom	Neuropathy, Hereditary Motor And Sensory, Lom Type
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d	Charcot-Marie-Tooth Neuropathy, Type 4d
Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d	Hmsn Lom Type
Hmsn, Lom Type	Hereditary Motor And Sensory Neuropathy, Lom Type
Charcot-Marie-Tooth Disease 4d	Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d
Hereditary Motor And Sensory Neuropathy Ivd	Hmsn Ivd

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09117	NDRG4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NDRG4	VGNC	VGNC:31941
Macaca mulatta	NDRG4	VGNC	VGNC:74955
Canis familiaris	NDRG4	VGNC	VGNC:43681
Felis catus	NDRG4	VGNC	VGNC:63755
Mus musculus	NDRG4	MGD	MGI:2384590
Rattus norvegicus	NDRG4	RGD	RGD:621593

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