SSX5 - SSX family member 5 Gene

Homo sapiens

Gene ID: 6758 | Gene type: protein coding

About SSX5

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,186,220-48,196,795 (from NCBI)

This gene has 3 transcripts (splice variants), 102 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]

SSX5 Products(2)

mRNA	Protein	Name
NM_021015.4	NP_066295.3	protein SSX5 isoform a
NM_175723.2	NP_783729.1	protein SSX5 isoform b

SSX5 Protein Structure

SSXRD

0
100
188 a.a.

Protein Preferred Names

Protein Names

protein SSX5

synovial sarcoma, X breakpoint 5

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial