2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. TMB-8

TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.

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TMB-8

TMB-8 Chemical Structure

CAS No. : 53464-72-5

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TMB-8 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.

Molecular Weight

431.99

Formula

C22H38ClNO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C(OC)=CC(C(OCCCCCCCCN(CC)CC)=O)=C1)OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3149 mL 11.5743 mL 23.1487 mL
5 mM 0.4630 mL 2.3149 mL 4.6297 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3149 mL 11.5743 mL 23.1487 mL 57.8717 mL
5 mM 0.4630 mL 2.3149 mL 4.6297 mL 11.5743 mL
10 mM 0.2315 mL 1.1574 mL 2.3149 mL 5.7872 mL
15 mM 0.1543 mL 0.7716 mL 1.5432 mL 3.8581 mL
20 mM 0.1157 mL 0.5787 mL 1.1574 mL 2.8936 mL
25 mM 0.0926 mL 0.4630 mL 0.9259 mL 2.3149 mL
30 mM 0.0772 mL 0.3858 mL 0.7716 mL 1.9291 mL
40 mM 0.0579 mL 0.2894 mL 0.5787 mL 1.4468 mL
50 mM 0.0463 mL 0.2315 mL 0.4630 mL 1.1574 mL
60 mM 0.0386 mL 0.1929 mL 0.3858 mL 0.9645 mL
80 mM 0.0289 mL 0.1447 mL 0.2894 mL 0.7234 mL
100 mM 0.0231 mL 0.1157 mL 0.2315 mL 0.5787 mL
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TMB-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMB-853464-72-5TMB8TMB 8Calcium ChannelCa2+ channelsCa channelsCa2+ antagonistInhibitorinhibitorinhibit

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