1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Bay K 8644

Bay K 8644 

Cat. No.: HY-10588 Purity: 98.16%
Handling Instructions

Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel.

For research use only. We do not sell to patients.

Bay K 8644 Chemical Structure

Bay K 8644 Chemical Structure

CAS No. : 71145-03-4

Size Stock
10 mM * 1 mL in DMSO Check price and availability
5 mg Check price and availability
10 mg Check price and availability

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Description

Bay K 8644, a dihydropyridine compound, is a specific L-type Ca2+ channel agonist. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel[1].

In Vitro

In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

356.30

Formula

C₁₆H₁₅F₃N₂O₄

CAS No.
SMILES

O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=C(C(F)(F)F)C=CC=C2)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (280.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8066 mL 14.0331 mL 28.0662 mL
5 mM 0.5613 mL 2.8066 mL 5.6132 mL
10 mM 0.2807 mL 1.4033 mL 2.8066 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Bay K 8644Bay K8644Bay K-8644Calcium ChannelCa2+ channelsCa channelsL-typeCa2+influxsarcolemmalInhibitorinhibitorinhibit

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Bay K 8644
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HY-10588
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