1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. (R)-(+)-Bay-K-8644

(R)-(+)-Bay-K-8644 

Cat. No.: HY-15125 Purity: 99.69%
Handling Instructions

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

For research use only. We do not sell to patients.

(R)-(+)-Bay-K-8644 Chemical Structure

(R)-(+)-Bay-K-8644 Chemical Structure

CAS No. : 98791-67-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 118 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-(+)-Bay-K-8644:

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Description

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

IC50 & Target

IC50: 975 nM (IBa)[1]

In Vitro

(R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644IBa[1]. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

356.30

Formula

C₁₆H₁₅F₃N₂O₄

CAS No.

98791-67-4

SMILES

CC1=C([N+]([O-])=O)[[email protected]](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 300 mg/mL (841.99 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8066 mL 14.0331 mL 28.0662 mL
5 mM 0.5613 mL 2.8066 mL 5.6132 mL
10 mM 0.2807 mL 1.4033 mL 2.8066 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.02 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.69%

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Keywords:

(R)-(+)-Bay-K-8644Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Product Name:
(R)-(+)-Bay-K-8644
Cat. No.:
HY-15125
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