1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. (S)-(-)-Bay-K-8644


Cat. No.: HY-15124 Purity: 98.52%
Handling Instructions

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

For research use only. We do not sell to patients.

(S)-(-)-Bay-K-8644 Chemical Structure

(S)-(-)-Bay-K-8644 Chemical Structure

CAS No. : 98625-26-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 178 In-stock
Estimated Time of Arrival: December 31
5 mg USD 162 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 888 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of (S)-(-)-Bay-K-8644:

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(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).

IC50 & Target

EC50: 32 nM (IBa)[1]

In Vitro

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[1]. The Ca2+ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca2+ channels[2]. The interactions of two Ca2+ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50=14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







CC1=C([N+]([O-])=O)[[email protected]@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (350.83 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8066 mL 14.0331 mL 28.0662 mL
5 mM 0.5613 mL 2.8066 mL 5.6132 mL
10 mM 0.2807 mL 1.4033 mL 2.8066 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.02 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.

Purity: 98.52%

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(S)-(-)-Bay-K-8644Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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