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Cat. No.: HY-106356

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GV-150013

GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect.

For research use only. We do not sell to patients.

CAS No.: 167355-22-8
Formula: C₃₃H₃₄N₄O₃
Molecular Weight:534.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

GV-150013 Chemical Structure

CAS No.: 167355-22-8

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect^[1].

IC₅₀ & Target

CCK-B^[1]

All Cholecystokinin Receptor Isoforms :

CCKAR
CCKBR

In Vivo

GV-150013 (0.5 - 60μg/kg, ip, Once) increase REM sleep and non-REM sleep in old rats model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Old rats ^[2].
Dosage:

0.5 μg/kg, 5μg/kg, 60μg/kg
Administration:

Intraperitoneal injection, Once
Result:

The duration of REM sleep and non-REM sleep was longer than that of control.

Chemical Information

CAS No. 167355-22-8
Molecular Weight 534.65
Formula C₃₃H₃₄N₄O₃
SMILES

O=C([C@@H](C1=O)NC(NC2=CC=CC=C2)=O)N(C3=CC=CC=C3)C4=CC=CC=C4N1CC56CC7CC(CC(C7)C6)C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Crespi F. Cholecystokinin-B (CCK-B) receptor antagonists improve "aged" sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):31-8. [Content Brief]

[2]. F.Crespi, et al. Influence of cholecystokinin-B (CCK-B) receptor antagonists on rat electroencephalography (EEG): A new class of sleep modulators? Gaviraghi. Dept of Pharmacology GlaxoWellcome S.p.A., Medicine Research Centre, via A. Fleming, 4, 37135 Verona, Italy

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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