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Art. -Nr.: HY-N21931

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Tetronothiodin

Name: Tetronothiodin
Brand: MedChemExpress
SKU: HY-N21931
Availability: PreOrder

(Synonyms: Ro 09-1468)

Tetronothiodin is a selective CCK_B receptor antagonist. Tetronothiodin inhibits rat CCK_B receptor binding with an IC₅₀ of 3.6 nM and human CCK_B receptor binding with an IC₅₀ of 210 nM, exhibiting species specificity. Tetronothiodin inhibits CCK-induced Ca²⁺ influx in pituitary cells. Tetronothiodin can be used in research related to CCK_B-mediated diseases.

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CAS. Nr.: 139643-79-1
Formel: C₃₁H₃₈O₈S
Molecular Weight:570.69

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Please store the product under the recommended conditions in the Certificate of Analysis.

Tetronothiodin Chemical Structure

CAS. Nr.: 139643-79-1

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Beschreibung

IC₅₀ & Target

^[1]

CCKBR

3.6 nM (IC₅₀)

Alle Cholecystokinin Receptor Isoform-spezifische Produkte anzeigen :

CCKAR
CCKBR

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Tetronothiodin is a competitive CCK_B receptor ligand in rat brain cortex membranes with an IC₅₀ of 3.6 nM; its affinity for rat pancreatic CCK_A receptors is very weak, indicating high CCK_B selectivity^[1].
Tetronothiodin inhibits the binding of [¹²⁵I]CCK-8 to CCK_B-rich regions of the rat forebrain in a concentration-dependent manner, almost completely abolishing binding at 1 µM, with the exception of the medial septum^[1].
Tetronothiodin inhibits the binding of [¹²⁵I]-CCK-8 to GH3 cells, with an IC₅₀ of 4.2 nM^[1].
Tetronothiodi is a selective CCK_B antagonist in GH3 rat anterior pituitary cells that inhibits CCK-8-induced Ca²⁺ mobilization with an IC₅₀ of 26 nM^[1].
Tetronothiodin binds to rat brain cortex CCK-B receptors in the ¹²⁵I-CCK-8 displacement assay with an IC₅₀ of 3.6 nM; it binds to human CCK-B receptors with an IC₅₀ of 210 nM, which is weaker than its activity against rat CCK-B receptors^[2].
Tetronothiodin can be produced by Streptomyces sp. NR0489^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ca²⁺ Staining Technique

Chemical Information

CAS. Nr. 139643-79-1
Molecular Weight 570.69
Formel C₃₁H₃₈O₈S
SMILES

O=C(C(C1SCC2C(C3=C(O)C4(CC(C)C(C)=CC4C/C=C\C=C/CC(C/C=C/CC(C12)C)O)OC3=O)=O)=O)O
Synonyms

Ro 09-1468
Initial Source
- Microorganism
Streptomyces sp. NR0489
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kuwahara T, et al. Tetronothiodin, a novel CCK_B receptor ligand, antagonizes cholecystokinin-induced Ca²⁺ mobilization in a pituitary cell line. European Journal of Pharmacology, 1992, 221(1):99-105.

[2]. Dunlop J. CCK Receptor Antagonists. General Pharmacology: The Vascular System, 1998, 31(4):519-524.

[3]. Ohtsuka T, et al. Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. J Antibiot (Tokyo). 1992 Jan;45(1):140-3.

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tetronothiodin

Alle Cholecystokinin Receptor Isoform-spezifische Produkte anzeigen

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