RP-69758
RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB)/gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261)-induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research.
For research use only. We do not sell to patients.
- CAS No.: 138562-23-9
- Formula: C26H26N4O5
- Molecular Weight:474.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RP-69758 exhibits high affinity for CCKB (Ki = 9.0 nM in guinea pig cortex; Ki = 4.3 nM in rat cerebral cortex; Ki = 5.0 nM in mouse brain) and gastrin receptors (Ki = 3.7 nM in gastric glands), and inhibits central CCK binding ex vivo in mice (IC50 = 17.6 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 138562-23-9
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Molecular Weight 474.51
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Formula C26H26N4O5
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SMILES
O=C(CC1=CC=CC(NC(NCC(N(C2=CC=CC=C2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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