RP-69758 

RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCK_B)/gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCK_B over CCK_A receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261)-induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research^[1].

RP-69758 exhibits high affinity for CCK_B (K_i = 9.0 nM in guinea pig cortex; K_i = 4.3 nM in rat cerebral cortex; K_i = 5.0 nM in mouse brain) and gastrin receptors (K_i = 3.7 nM in gastric glands), and inhibits central CCK binding ex vivo in mice (IC₅₀ = 17.6 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

474.51

C₂₆H₂₆N₄O₅

138562-23-9

O=C(CC1=CC=CC(NC(NCC(N(C2=CC=CC=C2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bertrand P, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45.  [Content Brief]