HCCS - holocytochrome c synthase Gene

Also Known as MLS; CCHL; MCOPS7; LSDMCA1

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 3052

Summary

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]

HCCS Products (1)

mRNA Protein Name
NM_001122608.3 NP_001116080.1 holocytochrome c-type synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
23150584 GOA
enables holocytochrome-c synthase activity IDA
IDA: Inferred from direct assay
23150584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in cytochrome c-heme linkage IDA
IDA: Inferred from direct assay
23150584 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
23150584 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
11827457 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

holocytochrome c-type synthase

  • cytochrome c heme-lyase

  • cytochrome c-type heme lyase

  • holocytochrome-c synthetase

  • microphthalamia with linear skin defects

  • microphthalmia with linear skin defects

HCCS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HCCS P53701 AGK Homo sapiens Q53H12
Anti Tag CoIP
33961781
Intra
HCCS P53701 AGK Homo sapiens Q53H12
Anti Tag CoIP
28514442
Intra
HCCS P53701 SNX1 Homo sapiens Q13596
Validated Y2H
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
HCCS P53701 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
HCCS P53701 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-17386 Rosiglitazone 99.94% Yes
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-15306 Eltrombopag 99.94% Yes
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-N7073 Silymarin Inhibitor 84.0% Unkown
HY-107193 Bacitracin Inhibitor / Yes
HY-B0402 Amantadine 99.90% Unkown
HY-15306A Eltrombopag Olamine 99.96% Yes
HY-B0402A Amantadine hydrochloride 98.0% Yes
HY-17386A Rosiglitazone hydrochloride 99.81% Yes
HY-100008 Peretinoin 99.79% Unkown
HY-N2591 Isocorydine 99.95% Unkown
HY-B0310 Nizatidine Antagonist 98.94% Unkown
HY-50767AR Palbociclib monohydrochloride (Standard) Inhibitor 99.95% Unkown
HY-17386B Rosiglitazone potassium 99.13% Yes
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-B0402B Amantadine sulfate / Unkown
HY-B0402R1 Amantadine in Methanol (Standard) / Unkown
HY-N2591A Isocorydine hydrochloride / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9971 Camrelizumab Inhibitor 98.80% Unkown
HY-P99108 Penpulimab Inhibitor 98.80% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-18750 Zorifertinib 99.37% Phase 3
HY-18750A Zorifertinib hydrochloride / Phase 3
HY-175538 USP10-IN-4 / Phase 3
HY-100492 Fisogatinib Inhibitor 99.87% Phase 2
HY-116000 Glumetinib Inhibitor 99.94% Phase 2
HY-16196 ENMD-1198 Inhibitor 98.87% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99013 Codrituzumab Inhibitor 99.07% Phase 2
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2

Pre-clinical Phase

Bioactive Molecules (216)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2334 Glycochenodeoxycholic acid 99.84% Unkown
HY-N0751 Scutellarin Inhibitor 99.57% Unkown
HY-16701 BV6 Antagonist 99.90% Unkown
HY-131045 HADA hydrochloride 98.01% Unkown
HY-16706A Remodelin hydrobromide Inhibitor 99.60% Unkown
HY-W015309 Decanoic acid Inhibitor 98.0% Unkown
HY-N2334A Glycochenodeoxycholic acid sodium salt 98.51% Unkown
HY-15449 Kaempferide 99.80% Unkown
HY-116761 GSK467 Inhibitor 99.34% Unkown
HY-N0220 Dauricine 99.75% Unkown
HY-N0070 Solasonine 99.19% Unkown
HY-111226 GSK5182 99.10% Unkown
HY-113261 Oleoylcarnitine 99.95% Unkown
HY-12794 Vps34-PIK-III Inhibitor 99.63% Unkown
HY-15897 LDN-212854 Inhibitor 99.62% Unkown
HY-N6739 Beauvericin 99.97% Unkown
HY-N0876 Arenobufagin Inducer 99.82% Unkown
HY-123921 Gefitinib-based PROTAC 3 Inhibitor 99.98% Unkown
HY-111126 K67 Inhibitor 98.26% Unkown
HY-178018 D574-0246 99.95% Unkown
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.99% Unkown
HY-N6712 Thiolutin Inhibitor 99.27% Unkown
HY-N0222 Avicularin 99.80% Unkown
HY-115449 Chromeceptin 99.80% Unkown
HY-139434 JMJD6-IN-1 Inhibitor 99.51% Unkown
HY-150750A ODN M362 sodium 97.02% Unkown
HY-175606 EVT0185 Inhibitor 99.39% Unkown
HY-121799A Taurohyocholic acid sodium salt 98.08% Unkown
HY-13267 Droxinostat 99.08% Unkown
HY-150750 ODN M362 96.01% Unkown
HY-175842 CDK2 degrader 7 Degrader 99.51% Unkown
HY-121799 Taurohyocholic acid 99.89% Unkown
HY-147918 Anticancer agent 73 Inhibitor 99.92% Unkown
HY-19345A Vacquinol-1 dihydrochloride Activator 99.70% Unkown
HY-19832 SC66 99.65% Unkown
HY-137506 XST-14 99.26% Unkown
HY-101519 BETd-260 99.68% Unkown
HY-121204 Iberverin Inducer 98.0% Unkown
HY-132177 α-L-Fucosidase, Microorganism / Unkown
HY-150538 STAT3-IN-12 99.87% Unkown
HY-157581 MS39 Degrader 99.89% Unkown
HY-160765 WNTinib 99.95% Unkown
HY-N2255 Crebanine 99.83% Unkown
HY-N8439 Questiomycin A 99.00% Unkown
HY-15485 Zardaverine 98.64% Unkown
HY-150072 DS89002333 Inhibitor 99.85% Unkown
HY-157950 DSPE-PEG2000-triGalNAc ammonium 99.8% Unkown
HY-N4168B Methyl chlorogenate 99.28% Unkown
HY-130173 Bafilomycin C1 99.9% Unkown
HY-142956 ROS-ERS inducer 1 99.12% Unkown
HY-W013514 2-Acetamidofluorene Inhibitor 99.50% Unkown
HY-10174 PD184161 98.08% Unkown
HY-N1260 Scutebarbatine A Inducer 98.76% Unkown
HY-N6623 Malvidin-3-galactoside chloride 99.63% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-159147 SIA​​IS039 99.68% Unkown
HY-146349 PROTAC EGFR degrader 4 Inhibitor 99.70% Unkown
HY-153901 PROTAC EGFR degrader 8 Inhibitor 98.90% Unkown
HY-155248 HL23 99.64% Unkown
HY-170791 CIB-L43 99.71% Unkown
HY-175646 AGPAT4-IN-1 99.04% Unkown
HY-N2282 Zingiberen newsaponin 99.68% Unkown
HY-164410 MO-I-1100 Inhibitor 99.76% Unkown
HY-175839 PROTAC EGFR degrader 15 99.23% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-131704 FGFR4-IN-5 Inhibitor 98.03% Unkown
HY-115901 4-PQBH 99.14% Unkown
HY-147187 MNK8 99.76% Unkown
HY-162616 SelSA 99.83% Unkown
HY-168574 SZU-B6 98.78% Unkown
HY-DY1044 HADA hydrochloride (solution) / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.87% Unkown
HY-W998347 ABS-752 hydrochloride 98.81% Unkown
HY-162259 QC-182 Degrader 98.94% Unkown
HY-162890 EGFR-IN-122 Inhibitor 99.98% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor 99.24% Unkown
HY-D2312 Mito-Rh-S 97.03% Unkown
HY-N1244 Sarmentosin 97.0% Unkown
HY-W011434 Triglycidyl isocyanurate 99.56% Unkown
HY-17386S1 Rosiglitazone-d4 99.72% Unkown
HY-N6739S Beauvericin-13C45 Inhibitor ≥99% Unkown
HY-19551 Apogossypolone 98.58% Unkown
HY-19617 EGFR-IN-1 Inhibitor / Unkown
HY-19617A EGFR-IN-1 hydrochloride Inhibitor / Unkown
HY-119833 Rubone Modulator 99.1% Unkown
HY-120349 LL-Z1640-4 Inhibitor 99.0% Unkown
HY-120766 NCDM-32B Inhibitor 97.0% Unkown
HY-162650 SL44 Inhibitor 99.57% Unkown
HY-16701A BV6 TFA Antagonist 99.61% Unkown
HY-169262 PLD-IN-1 99.18% Unkown
HY-19617B EGFR-IN-1 TFA Inhibitor 99.38% Unkown
HY-N12378 β-Patchoulene 96.88% Unkown
HY-N8540 Ilicicolin H 96.7% Unkown
HY-P10553 ARF(26-44), cell-permeable Inhibitor / Unkown
HY-P10553A ARF(26-44), cell-permeable acetate Inhibitor 99.12% Unkown
HY-W011616 Cardionogen 1 Inhibitor 99.21% Unkown
HY-W266188 Decanoic acid-13C 98.0% Unkown
HY-152169 BIHC ≥98.0% Unkown
HY-N11429 Glycochenodeoxycholic acid 3-glucuronide / Unkown
HY-178114 SKLB-0124 / Unkown
HY-100443 PX20606 Agonist / Unkown
HY-146407 Anticancer agent 53 Inducer / Unkown
HY-147515 FGFR4-IN-11 Inhibitor / Unkown
HY-151287 KRAS inhibitor-20 Inhibitor / Unkown
HY-101021 Ascochlorin / Unkown
HY-113261R Oleoylcarnitine (Standard) / Unkown
HY-115902 FGFR4-IN-7 / Unkown
HY-120356 T-1101 / Unkown
HY-121160 Amiprilose Inhibitor / Unkown
HY-130133 DHW-221 / Unkown
HY-141813 Autophagy-IN-C1 Inhibitor / Unkown
HY-142945 KRAS G12C inhibitor 43 Inhibitor / Unkown
HY-143881 FGFR4-IN-6 Inhibitor / Unkown
HY-144605 PROTAC EGFR degrader 3 Inhibitor 97.39% Unkown
HY-144724 HSP90-IN-10 Inhibitor / Unkown
HY-144759 FGFR4-IN-9 Inhibitor / Unkown
HY-145389 SZ-015268 Inhibitor / Unkown
HY-146395 HBV-IN-23 / Unkown
HY-146422 PROTAC EGFR degrader 5 / Unkown
HY-146423 PROTAC EGFR degrader 6 / Unkown
HY-146504 Topoisomerase I/II inhibitor 3 / Unkown
HY-147793 FGFR4-IN-12 Inhibitor / Unkown
HY-149063 Antitumor agent-92 Inducer / Unkown
HY-149475 VEGFR-2-IN-33 Inhibitor / Unkown
HY-150596 CT1-3 / Unkown
HY-151461 CHNQD-01255 Inhibitor / Unkown
HY-155046 FGFR4-IN-14 Inhibitor / Unkown
HY-155139 Tubulin polymerization-IN-45 / Unkown
HY-155172 ZX-J-19j / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-158248 FGFR4-IN-19 Inhibitor / Unkown
HY-158439 anti-TNBC agent-7 Modulator / Unkown
HY-161373 PI3Kα-IN-22 Inhibitor / Unkown
HY-161617 LASSBio-2052 / Unkown
HY-161647 Antitumor agent-156 Inducer / Unkown
HY-161706 c-Fms-IN-15 Inhibitor / Unkown
HY-161825 Tubulin polymerization-IN-66 / Unkown
HY-161854 LASSBio-1911 Inhibitor / Unkown
HY-161934 PARP1-IN-27 / Unkown
HY-162099 VEGFR-IN-4 Inhibitor / Unkown
HY-162679 c-Met degrader-1 / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-164349 WZ-2-033 Inhibitor / Unkown
HY-164372 17-Demethoxy-reblastatin / Unkown
HY-168085 CV-4-26 / Unkown
HY-168165 Adefovir diphosphate / Unkown
HY-168187 Src Inhibitor 3 Inhibitor / Unkown
HY-168337 SET-171 Inhibitor / Unkown
HY-168609 CRI9 / Unkown
HY-168872 API32 Inhibitor / Unkown
HY-169431 VEGFR-2/AKT-IN-2 / Unkown
HY-170549 VEGFR-2-IN-60 Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 / Unkown
HY-170690 FGFR4-IN-22 Inhibitor / Unkown
HY-171789 PARG-IN-7 Inhibitor / Unkown
HY-172499 DSPE-PEG1000-Mal-CLPLIPTHIISFS / Unkown
HY-172500 DSPE-PEG2000-Mal-CLPLIPTHIISFS 95.0% Unkown
HY-172500A DSPE-PEG3400-Mal-CLPLIPTHIISFS / Unkown
HY-172501 DSPE-PEG5000-Mal-CLPLIPTHIISFS / Unkown
HY-172881 PKM2-IN-10 Inhibitor / Unkown
HY-172885 TRBP-IN-1 / Unkown
HY-172957 JNN-5 Inhibitor / Unkown
HY-173038 EGFR-IN-151 / Unkown
HY-173060 ERK1/2 inhibitor 13 / Unkown
HY-173453 AKR1C3-IN-15 / Unkown
HY-174411 Tubulin polymerization-IN-82 / Unkown
HY-175037 DNH28 / Unkown
HY-175235 MEK4 IN-3 Inhibitor / Unkown
HY-175283 ABT-002 Degrader / Unkown
HY-175553 VEGFR-2-IN-72 / Unkown
HY-175819 PD-166285 / Unkown
HY-17654 BIEGi-1 Inhibitor / Unkown
HY-176957 PKMYT1-IN-11 Inhibitor / Unkown
HY-177269 CHNQD-01269 Inhibitor / Unkown
HY-178098 TEAD-IN-21 Inhibitor / Unkown
HY-179033 Nur77 antagonist 2 / Unkown
HY-179035 TBS6b Degrader / Unkown
HY-179243 S3D5 / Unkown
HY-179381 FGFR4-IN-24 Inhibitor / Unkown
HY-179385 Tubulin-IN-62 / Unkown
HY-179427 NSD2/H3K36me2 modulator-1 / Unkown
HY-179430 TTK-IN-5 Inhibitor / Unkown
HY-180281 PLAGL2-IN-1 / Unkown
HY-180355 SY-5102 / Unkown
HY-181004 PKMYT1-IN-13 Inhibitor / Unkown
HY-183753 LC-TD-05 / Unkown
HY-184204 Keap1-p-p62-IN-1 / Unkown
HY-184448 CIB-Q22 / Unkown
HY-E70272 2-Hydroxystearoyl-CoA / Unkown
HY-N12601 Diselaginellin B Inducer / Unkown
HY-N16400 Aspergillumarin A Inhibitor / Unkown
HY-N7803 De-O-Methyllasiodiplodin Inducer / Unkown
HY-P11618 10P3Me Ligand / Unkown
HY-P11814 cTMTP1 / Unkown
HY-P11816 DOTA-cTMTP1 / Unkown
HY-W478417 (R)-Etodolac Inhibitor / Unkown
HY-W653905 Amantadine-d15 hydrochloride / Unkown
HY-W717425 SC-60 / Unkown
HY-W718678 6-Hydroxymelatonin glucuronide / Unkown
HY-123697 VE-465 Inhibitor / Unkown
HY-164384 DFX117 / Unkown
HY-164520 PMED-1 Inhibitor / Unkown
HY-173387 4F-Docetaxel / Unkown
HY-N2858 Alpinumisoflavone acetate Inducer / Unkown
HY-N5186 Cypemycin Inhibitor / Unkown
HY-N7507A Sempervirine nitrate Inhibitor / Unkown
HY-RS16314 HCC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16456 HCCS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22197 Hccs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28719 Hccs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W587561 Glycochenodeoxycholic acid 3-glucuronide disodium / Unkown
HY-W713365 Eltrombopag-d3 / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990297 Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Inhibitor 99.5% Unkown
HY-P990840 Anti-GPC3 Antibody (YP7) Inhibitor ≥95.0% Unkown
HY-P990841 Anti-pan-Glypican Antibody (HS20) Inhibitor 99.44% Unkown
HY-P990175 Anti-Mouse OX40L/CD134L Antibody (RM134L) Inhibitor 95.00% Unkown
HY-P99108A Penpulimab (Anti-PD-1) Inhibitor / Unkown
HY-P991328 MAb604.107 Inhibitor / Unkown
HY-P990867 Anti-CD220/Insulin Receptor Antibody (IR 83-22) Inhibitor / Unkown