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  2. Epigenetic Reader Domain PROTACs
  3. PROTAC BRD4 Degrader-27

PROTAC BRD4 Degrader-27 is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3). PROTAC BRD4 Degrader-27 consists of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker γ-Aminobutyric acid (HY-N0067) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (HY-162876), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875).

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PROTAC BRD4 Degrader-27 Chemical Structure

PROTAC BRD4 Degrader-27 Chemical Structure

CAS No. : 2407163-44-2

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Description

PROTAC BRD4 Degrader-27 is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3). PROTAC BRD4 Degrader-27 consists of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596), PROTAC Linker γ-Aminobutyric acid (HY-N0067) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (HY-162876), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875)[1].

IC50 & Target

BRD4[1]

Molecular Weight

708.67

Formula

C37H30F2N6O7

CAS No.
SMILES

CN1C=C(C2=C(C1=O)NC=C2)C3=CC(NC(CCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC=C3OC7=CC=C(C=C7F)F

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Product Name:
PROTAC BRD4 Degrader-27
Cat. No.:
HY-162875
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