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Cat. No.: HY-162875

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PROTAC BRD4 Degrader-27

PROTAC BRD4 Degrader-27 (compound 6b) is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3) and can also inhibit the expression of KLF5 transcription factor and exert anti-cancer activity^{[1]^{.

(Pink: BRD4 ligand (HY-162876); Blue: Cereblon ligand (HY-103596); Black: linker (HY-N0067)).}}

For research use only. We do not sell to patients.

CAS No.: 2407163-44-2
Formula: C₃₇H₃₀F₂N₆O₇
Molecular Weight:708.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC BRD4 Degrader-27 Chemical Structure

CAS No.: 2407163-44-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC BRD4 Degrader-27 (compound 6b) is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3) and can also inhibit the expression of KLF5 transcription factor and exert anti-cancer activity^{[1]^{.
(Pink: BRD4 ligand (}HY-162876); Blue: Cereblon ligand (HY-103596); Black: linker (HY-N0067)).}

IC₅₀ & Target

BRD4^[1]

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

CAS No. 2407163-44-2
Molecular Weight 708.67
Formula C₃₇H₃₀F₂N₆O₇
SMILES

CN1C=C(C2=C(C1=O)NC=C2)C3=CC(NC(CCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC=C3OC7=CC=C(C=C7F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kong Y, et al. BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression. Oncogene. 2024 Sep;43(39):2914-2926. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PROTAC BRD4 Degrader-27

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BRD4 Degrader-27 Related Classifications

HY-162875 Related Classifications