2407163-44-2
2407163-44-2
Chemical Structure
PROTAC BRD4 Degrader-27
- CAS No.: 2407163-44-2
- Formula:C37H30F2N6O7
- Molecular Weight:708.67
InChIKey: ZOXPSMPLTDCNLS-UHFFFAOYSA-N
SMILES: CN1C=C(C2=C(C1=O)NC=C2)C3=CC(NC(CCCNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC=C3OC7=CC=C(C=C7F)F
Biological Activity: PROTAC BRD4 Degrader-27 is a selective cereblon-mediated BRD4 PROTAC degrader. PROTAC BRD4 Degrader-27 exhibits anticancer activity, induces G1 phase arrest, and inhibits DNA synthesis and colony formation. PROTAC BRD4 Degrader-27 suppresses HCC1806 tumor growth in xenograft mouse models. PROTAC BRD4 Degrader-27 can be used in breast cancer-related research[1].
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PROTAC BRD4 Degrader-27 | PROTAC BRD4 Degrader-27 is a selective cereblon-mediated BRD4 PROTAC degrader. PROTAC BRD4 Degrader-27 exhibits anticancer activity, induces G1 phase arrest, and inhibits DNA synthesis and colony formation. PROTAC BRD4 Degrader-27 suppresses HCC1806 tumor growth in xenograft mouse models. PROTAC BRD4 Degrader-27 can be used in breast cancer-related research. | |||||||||||||||||||||
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