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Cat. No.: HY-170690

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FGFR4-IN-22

FGFR4-IN-22 (compound 10f) is a potent inhibitor of FGFR4, with the IC₅₀ of 5.4 nM. FGFR4-IN-22 serve as a potential lead compound targeting FGFR4 for anti-HCC agent development.

For research use only. We do not sell to patients.

CAS No.: 2922812-74-4
Formula: C₃₆H₃₄F₃N₇O₂
Molecular Weight:653.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

FGFR4-IN-22 Chemical Structure

CAS No.: 2922812-74-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

FGFR4-IN-22 (compound 10f) is a potent inhibitor of FGFR4, with the IC₅₀ of 5.4 nM. FGFR4-IN-22 serve as a potential lead compound targeting FGFR4 for anti-HCC agent development^[1].

IC₅₀ & Target

FGFR4

5.4 nM (IC₅₀)

Chemical Information

CAS No. 2922812-74-4
Molecular Weight 653.70
Formula C₃₆H₃₄F₃N₇O₂
SMILES

O=C(NC1=CC=CC(C)=C1NC2=NC=C(C=N2)C#CC3=CC=CC(C(NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4)=O)=C3)C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei Han, et al. Design, synthesis, and biological evaluation of Ponatinib-based N-Phenylpyrimidine-2-amine derivatives as novel fibroblast growth factor receptor 4 (FGFR4) selective inhibitors. Eur J Med Chem. 2025 Feb 15:284:117206. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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