1. PI3K/Akt/mTOR
  2. Akt

SC66 

Cat. No.: HY-19832
Handling Instructions

SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 μg/ml at 72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells.

For research use only. We do not sell to patients.
SC66 Chemical Structure

SC66 Chemical Structure

CAS No. : 871361-88-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg $250 In-stock
100 mg $400 In-stock
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500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 μg/ml at 72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells. IC50 value: 0.75 μg/ml (72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells) [1] Target: Akt in vitro: Each cell line had a different sensitivity to SC66, as evidenced by the IC50 values . HepG2, HA22T/VGH and PLC/PRF/5 cells had similar IC50 values of approximately 0.85 and 0.75 μg/ml at 48 and 72 hours, respectively. The most resistant cell line was Huh7, which showed an IC50 of 3.1 and 2.8 μg/ml at 48 and 72 hours respectively, while the Hep3B cell line was found to be the most sensitive, with an IC50 of 0.75 and 0.5 μg/ml at 48 and 72 hours, respectively. SC66 reducew cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reduction in total and phospho-AKT levels. In addition, SC66 induces the production of reactive oxygen species (ROS) and DNA damage. SC66 significantly potentiates the effects of both conventional chemotherapeutic and targeted agents, doxorubicin and everolimus, respectively. [1] SC66 manifests a more effective growth suppression of transformed cells compared with other inhibitors of PIP3/Akt pathway. SC66 represents a unique chemical tool to investigate the mechanisms of ubiquitination-dependent Akt regulation in physiological and stressed conditions. SC66 directly facilitates Akt ubiquitination. [2] In vivo: SC66 inhibits tumor growth of Hep3B cells in xenograft models. [1]

References
Molecular Weight

276.33

Formula

C₁₈H₁₆N₂O

CAS No.

871361-88-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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SC66
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