1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Camrelizumab

Camrelizumab (Synonyms: SHR-1210)

Cat. No.: HY-P9971
Handling Instructions

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al.

For research use only. We do not sell to patients.

Camrelizumab Chemical Structure

Camrelizumab Chemical Structure

CAS No. : 1798286-48-2

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Description

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al[1][2].

IC50 & Target

IC50: 0.70 nM ( PD-1/PD-L1 interaction)[1]

In Vitro

In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Camrelizumab (3 mg/kg) combines with apatinib (200 and 100 mg/kg) inhibits the tumor inhibition rates reached 63.1% and 87.3%, respectively in human PD-1 transgenic mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
SMILES

[Camrelizumab]

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Keywords:

CamrelizumabSHR-1210SHR1210SHR 1210PD-1/PD-L1PD-1/Programmed death-ligand 1chemotherapynon-squamousNSCLCESCCEsophageal squamous cell carcinomahepatocellular carcinomaHodgkin lymphomaadvanced HCCanticancer treatmentanti-PD-1anti-PD-L1Inhibitorinhibitorinhibit

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Camrelizumab
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