Hodgkin Lymphoma

Hodgkin lymphoma is a distinct type of lymphoma characterized by the presence of Reed-Sternberg cells, differentiating it from non-Hodgkin lymphomas, which include a heterogeneous group of malignancies arising from B-cell or T-cell lineages. T-cell non-Hodgkin lymphoma specifically originates from T-lymphocytes and encompasses various subtypes with differing clinical behaviors and prognoses.

References:

[1]. T-Cell Non-Hodgkin Lymphoma. malacards.

Hodgkin Lymphoma (4):

Targets:	STAT (1) TNF Receptor (1) Interleukin Related (1) PROTACs (1) DNA/RNA Synthesis (1) DNA Alkylator/Crosslinker (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-169179

AK-1690	2984505-88-4	99.91%
AK-1690 is a selective PROTAC degrader targeting STAT6 (DC₅₀=1 nM) with a K_i of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc..

HY-13747

Semustine	13909-09-6	98.0%
Semustine is an orally active, blood-brain barrier permeable antitumor alkylating agent with a binding affinity of 1.53 × 10³ M^-1 for guanine and thymine residues in bovine DNA. Semustine undergoes major groove-directed alkylation at guanine residues to form O6-chloroethylguanine and N1-O6-ethanoguanine adducts, and generates dG-dC interstrand crosslinks. Semustine induces partial B- to C-type transition of DNA, base stacking and helical structure distortion, mild dehydration, as well as partial DNA double-strand unwinding. Semustine can be used in research related to Lewis lung cancer, leukemia, Hodgkin's lymphoma, malignant melanoma, glioma, and diffuse large B-cell lymphoma.

HY-P992404

MDX-1401
MDX-1401 is a fully human IgG1 (κ isotype) monoclonal antibody against CD30, with a K_d value of 0.83 nmol/L. MDX-1401 induces antibody-dependent cellular cytotoxicity in CD30-expressing cells and inhibits tumor growth in CD30⁺ lymphoma xenograft models. MDX-1401 can be used in research related to malignant lymphoma and Hodgkin lymphoma.

HY-P992032

TPP-9476
TPP-9476 (BAY-943 antibody) is an anti-human IL3RA (CD123) monoclonal antibody with human IL3RA K_d of 11 nM and cynomolgus monkey IL3RA K_d of 16 nM. TPP-9476 binds specifically to human and cynomolgus monkey IL3RA, undergoes target-dependent internalization into lysosomes of IL3RA-positive cells.TPP-9476 exerts antiproliferative effects in IL3RA-expressing acute myeloid leukemia and classical Hodgkin lymphoma cells, reduces tumor burden, improves survival, and induces complete tumor remission in relevant xenograft mouse models.

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