55-98-1
55-98-1
Chemical Structure
Busulfan
- CAS No.: 55-98-1
- Formula:C6H14O6S2
- Molecular Weight:246.30
IUPAC Name: butane-1,4-diyl dimethanesulfonate
InChIKey: COVZYZSDYWQREU-UHFFFAOYSA-N
SMILES: CS(=O)(OCCCCOS(C)(=O)=O)=O
Biological Activity: Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Busulfan | 99.90% | Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent. | ||||||||||||||||||||
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Busulfan (Standard) | 99.86% | Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent. | ||||||||||||||||||||
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Busulfan solution | Busulfan solution is mainly composed of Busulfan (HY-B0245). Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent. | |||||||||||||||||||||
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Busulfan-d8 | 99.73% | Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-129524REthylene dimethanesulfonate (Standard) -
Similarity Score 0.90
HY-140382Ms-PEG2-MS -
Similarity Score 0.79
HY-43948RHexyl methanesulfonate (Standard) -
Similarity Score 0.78
HY-166217Heptyl methane sulfonate -
Similarity Score 0.77
HY-140362m-PEG2-MS -
Similarity Score 0.77
HY-165735Octyl methane sulfonate -
Similarity Score 0.76
HY-W848341Clomesone -
Similarity Score 0.76
HY-W017796RButyl methanesulfonate (Standard) -
Similarity Score 0.76
HY-132042Bromo-PEG2-MS -
Explore the MedChemAI to find more analogs
References
- [1]. Probin V, et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42(12):1858-65. Epub 2007 Mar 31. [Content Brief]
- [2]. Mattan Levi, et al. Treosulfan induces distinctive gonadal toxicity compared with busulfan. Oncotarget. 2018 Apr 10;9(27):19317-19327. [Content Brief]
- [3]. Janka Reimer, et al. Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol. 2012 Jun;68(6):923-35. [Content Brief]
