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Cat. No.: HY-W848341

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Clomesone

(Synonyms: NSC 338947; CIEtSoSo)

Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.

For research use only. We do not sell to patients.

CAS No.: 88343-72-0
Formula: C₄H₉ClO₅S₂
Molecular Weight:236.69

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Clomesone Chemical Structure

CAS No.: 88343-72-0

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Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	3 μM Compound: 10	In vitro growth inhibition against L1210 murine leukemia cells In vitro growth inhibition against L1210 murine leukemia cells	[PMID: 2342050]

Chemical Information

CAS No. 88343-72-0
Molecular Weight 236.69
Formula C₄H₉ClO₅S₂
SMILES

O=S(OCCCl)(CS(=O)(C)=O)=O
Synonyms

NSC 338947; CIEtSoSo
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pre-clinical evaluation of a novel chloroethylating agent, Clomesone [Content Brief]

[2]. M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. Cancer Res. 1988 Jul 1;48(13):3603-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Clomesone

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Clomesone Related Classifications

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