PROTAC BCL-xL/BCL-w Degrader 1
PROTAC BCL-xL/BCL-w Degrader 1 is a selective BCL-xL/BCL-w PROTAC degrader. PROTAC BCL-xL/BCL-w Degrader 1 promotes ubiquitination and degradation of BCL-xL and BCL-w, without affecting BCL-2. PROTAC BCL-xL/BCL-w Degrader 1 can be used for the research of Hodgkin lymphoma.
(Pink: Bcl-xL and Bcl-W ligand (HY-10087); Blue: Cereblon ligand (HY-163233); Black: linker (HY-Y1230)).
For research use only. We do not sell to patients.
- Formula: C69H77ClF3N9O10S3
- Molecular Weight:1381.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
Bcl-xL |
Bcl-W |
Cereblon |
In Vitro
PROTAC BCL-xL/BCL-w Degrader 1 (Compound 44) (10-1000 nM; 16 h) potently degrades BCL-xL in HeLa cells without affecting BCL-2[1].
PROTAC BCL-xL/BCL-w Degrader 1 (10-100 nM; 1-72 h) potently degrades BCL-xL in RS4;11 cells, but has no effect on BCL-2[1].
PROTAC BCL-xL/BCL-w Degrader 1 effectively degrades BCL-xL and BCL-w in WI-38 lung fibroblasts, with potency superior to that of the BCL-xL selective degrader PZ15227[1].
PROTAC BCL-xL/BCL-w Degrader 1 mediates the degradation of BCL-xL and BCL-w in WI-38 and HeLa cells via a PROTAC mechanism dependent on functional proteasome and CRBN E3 ligase[1].
PROTAC BCL-xL/BCL-w Degrader 1 potently inhibits the proliferation of Hs 445 Hodgkin's lymphoma cells, and its efficacy is approximately 2-fold higher than that of PZ15227, a selective BCL-xL degrader[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:10 nM; 100 nM; 1000 nM
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Incubation Time:16 h
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Result:Induced degradation of BCL-xL protein.
Showed no significant reduction in BCL-2 protein levels.
Chemical Information
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Molecular Weight 1381.05
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Formula C69H77ClF3N9O10S3
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SMILES
ClC(C=C1)=CC=C1C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C(C#CCCC(N8CCN(C9=CC=C(C(N(C%10CCC(NC%10=O)=O)C%11)=O)C%11=C9)CC8)=O)=C5)=O)=O)C=C4)CC3)CC(C)(C)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC BCL-xL/BCL-w Degrader 1 Related Classifications
HY-178066 Related Classifications
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