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Thiolutin (Synonyms: Acetopyrrothin)

Cat. No.: HY-N6712
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Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.

For research use only. We do not sell to patients.

Thiolutin Chemical Structure

Thiolutin Chemical Structure

CAS No. : 87-11-6

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Description

Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36[1]. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation[2].

Molecular Weight

228.29

Formula

C₈H₈N₂O₂S₂

CAS No.

87-11-6

SMILES

CC(NC1=C2C(N(C)C1=O)=CSS2)=O

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Thiolutin
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