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  2. HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
  3. Lovastatin

Lovastatin  (Synonyms: Mevinolin)

Cat. No.: HY-N0504 Purity: 98.91%
COA Handling Instructions

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

For research use only. We do not sell to patients.

Lovastatin Chemical Structure

Lovastatin Chemical Structure

CAS No. : 75330-75-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 33 In-stock
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10 mg USD 30 In-stock
50 mg USD 55 In-stock
100 mg USD 80 In-stock
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Customer Review

Based on 20 publication(s) in Google Scholar

Other Forms of Lovastatin:

Top Publications Citing Use of Products

    Lovastatin purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2022 Dec 15;209:105497.  [Abstract]

    Pretreatment with AY9944 (15, 30 µM), U18666A (5, 10 µM), lovastatin (5, 10 µM) and MβCD for 2 h can all significantly reduce the level of EV-A71 VP1 protein in HCT-8 cell.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

    IC50 & Target

    HMG-CoA reductase[1]

    In Vitro

    Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells[2].
    ? Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: HepG2 cells
    Concentration: 10 μM
    Incubation Time: 72 hours
    Result: Efficiently reduced viability of HepG2 cells.
    In Vivo

    Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight




    CAS No.



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    Structure Classification
    Initial Source

    aspergillus terreus


    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (247.19 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4719 mL 12.3597 mL 24.7194 mL
    5 mM 0.4944 mL 2.4719 mL 4.9439 mL
    10 mM 0.2472 mL 1.2360 mL 2.4719 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.89%

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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