1. Metabolic Enzyme/Protease
    Autophagy
    Apoptosis
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Ferroptosis
  3. Lovastatin

Lovastatin (Synonyms: Mevinolin)

Cat. No.: HY-N0504 Purity: 99.93%
Handling Instructions

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

For research use only. We do not sell to patients.

Lovastatin Chemical Structure

Lovastatin Chemical Structure

CAS No. : 75330-75-5

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Lovastatin:

Top Publications Citing Use of Products
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Description

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

IC50 & Target

HMG-CoA reductase[1]

In Vitro

Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells[2].
Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 10 μM
Incubation Time: 72 hours
Result: Efficiently reduced viability of HepG2 cells.
In Vivo

Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

404.54

Formula

C24H36O5

CAS No.
SMILES
Structure Classification
Source

aspergillus terreus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (247.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4719 mL 12.3597 mL 24.7194 mL
5 mM 0.4944 mL 2.4719 mL 4.9439 mL
10 mM 0.2472 mL 1.2360 mL 2.4719 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.93%

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Lovastatin
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