1. Metabolic Enzyme/Protease
    Autophagy
    Apoptosis
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
    Ferroptosis
  3. Lovastatin

Lovastatin (Synonyms: Mevinolin)

Cat. No.: HY-N0504 Purity: 99.89%
Handling Instructions

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

For research use only. We do not sell to patients.

Lovastatin Chemical Structure

Lovastatin Chemical Structure

CAS No. : 75330-75-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

IC50 & Target

HMG-CoA reductase[1]

In Vitro

Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells[2].
Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells[2].

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 10 μM
Incubation Time: 72 hours
Result: Efficiently reduced viability of HepG2 cells.
In Vivo

Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].

Clinical Trial
Molecular Weight

404.54

Formula

C₂₄H₃₆O₅

CAS No.

75330-75-5

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (247.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4719 mL 12.3597 mL 24.7194 mL
5 mM 0.4944 mL 2.4719 mL 4.9439 mL
10 mM 0.2472 mL 1.2360 mL 2.4719 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.89%

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Keywords:

LovastatinMevinolinHMG-CoA Reductase (HMGCR)AutophagyFerroptosisInhibitorinhibitorinhibit

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Lovastatin
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