1. Metabolic Enzyme/Protease Autophagy Apoptosis
  2. HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
  3. Lovastatin

Lovastatin  (Synonyms: Mevinolin)

Cat. No.: HY-N0504 Purity: 98.91%
COA Handling Instructions

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

For research use only. We do not sell to patients.

Lovastatin Chemical Structure

Lovastatin Chemical Structure

CAS No. : 75330-75-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 20 publication(s) in Google Scholar

Other Forms of Lovastatin:

Top Publications Citing Use of Products

    Lovastatin purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2022 Dec 15;209:105497.  [Abstract]

    Pretreatment with AY9944 (15, 30 µM), U18666A (5, 10 µM), lovastatin (5, 10 µM) and MβCD for 2 h can all significantly reduce the level of EV-A71 VP1 protein in HCT-8 cell.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

    IC50 & Target

    HMG-CoA reductase[1]

    In Vitro

    Lovastatin (10 μM; 72 hours) efficiently reduces viability of HepG2 cells[2].
    ? Lovastatin (10 μM; 48 hours) induces apoptosis in HepG2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: HepG2 cells
    Concentration: 10 μM
    Incubation Time: 72 hours
    Result: Efficiently reduced viability of HepG2 cells.
    In Vivo

    Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    404.54

    Formula

    C24H36O5

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@@H](C)CC)O[C@@H]1[C@@]([C@H]2CC[C@@H](OC3=O)C[C@H](C3)O)([H])C(C=C[C@@H]2C)=C[C@H](C)C1

    Structure Classification
    Initial Source

    aspergillus terreus

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (247.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4719 mL 12.3597 mL 24.7194 mL
    5 mM 0.4944 mL 2.4719 mL 4.9439 mL
    10 mM 0.2472 mL 1.2360 mL 2.4719 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.89%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
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