Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29

  • Bioorg Med Chem Lett. 2015 Sep 1;25(17):3606-9. doi: 10.1016/j.bmcl.2015.06.072.
Meilin Zhu  1 ,  Huquan Gao  1 ,  Chongming Wu  2 ,  Tianjiao Zhu  1 ,  Qian Che  1 ,  Qianqun Gu  1 ,  Peng Guo  3 ,  Dehai Li  4
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • 2. Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China.
  • 3. Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China. Electronic address: [email protected].
  • 4. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China. Electronic address: [email protected].
PMID: 26169125 DOI: 10.1016/j.bmcl.2015.06.072
Abstract

Two new C12 polyketides, cladospolides E and F (1 and 2), together with four known derivatives seco-patulolides A and C (3 and 4), 11-hydroxy-γ-dodecalactone (5) and iso-cladospolide B (6), were isolated from a soft coral-derived fungus Cladosporium sp. TZP-29. Their structures, including the absolute configurations, were elucidated by spectroscopic analysis, modified Mosher's method, and the analysis of their biogenesis. All compounds were non-cytotoxic while compounds 1 and 3-5 showed potent lipid-lowering activity in HepG2 hepatocytes.

Keywords
Cladosporium sp.; Lipid-lowering activity; Secondary metabolites; Soft coral-derived fungus.