Lovastatin hydroxy acid sodium
Based on 1 Customer Validation
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
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- Pureté: 99.50%
- CAS No.: 75225-50-2
- Formule: C24H37NaO6
- Masse moléculaire:444.54
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Ki: 0.6 nM (HMG-CoA reductase)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
0.146 μM
Compound: 1b
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Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
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[PMID: 2231594] |
| HepG2 | IC50 |
29 nM
Compound: mevinolin (salt)
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Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
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[PMID: 1527791] |
| HES | IC50 |
17 nM
Compound: mevinolin (salt)
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Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
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[PMID: 1527791] |
Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75225-50-2
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Appearance Solid
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Masse moléculaire 444.54
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Formule C24H37NaO6
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Color White to light yellow
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SMILES
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O[Na]
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Synonyms
Mevinolinic acid sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2495 mL | 11.2476 mL | 22.4952 mL | 56.2379 mL |
| 5 mM | 0.4499 mL | 2.2495 mL | 4.4990 mL | 11.2476 mL | |
| 10 mM | 0.2250 mL | 1.1248 mL | 2.2495 mL | 5.6238 mL | |
| 15 mM | 0.1500 mL | 0.7498 mL | 1.4997 mL | 3.7492 mL | |
| 20 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8119 mL | |
| 25 mM | 0.0900 mL | 0.4499 mL | 0.8998 mL | 2.2495 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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