Lovastatin acid
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia.
It is advisable to consider the salt form (Lovastatin hydroxy acid sodium) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 75225-51-3
- Formula: C24H38O6
- Molecular Weight:422.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of Lovastatin acid
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-100793
SR12813HMG-CoA Reductase Inhibitor/hPXR Agonist -
HY-17504B
Rosuvastatin SodiumHMGCR Inhibitor -
HY-104051
Monacolin JCholesterol Biosynthesis Inhibitor -
HY-19671
ApomineHMGR Inhibitor -
HY-114316
HMG499HMGCR Degrader -
HY-129458
CerivastatinHMG-CoA Reductase Inhibitor -
HY-100793R
SR12813 (Standard)HMG-CoA Reductase Inhibitor/hPXR Agonist -
HY-17504BR
Rosuvastatin Sodium (Standard)Reference Standard -
HY-17504C
(3R,5R)-RosuvastatinhERG Potassium Channel Blocker/HMG-CoA Reductase Inhibitor
Biological Activity
Description
IC50 & Target
Ki: 0.6 nM (HMG-CoA reductase)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
4 μM
Compound: Lovastatin acid
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TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17beta-glucuronide:0.02uM) in OATP1B1-expressing HEK293 cells
TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17beta-glucuronide:0.02uM) in OATP1B1-expressing HEK293 cells
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[PMID: 15616150] |
In Vitro
Lovastatin acid (Compound sodium mevinolinate) potently inhibits partially purified activated HMG-CoA reductase with a competitive Ki of 0.64 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 75225-51-3
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Molecular Weight 422.55
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Formula C24H38O6
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SMILES
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O
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Synonyms
Mevinolinic acid; MSD803
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lovastatin acid Related Classifications
HY-122439 Related Classifications
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