1. Protein Tyrosine Kinase/RTK
  2. FGFR

BLU-554 

Cat. No.: HY-100492 Purity: 99.84%
Handling Instructions

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.

For research use only. We do not sell to patients.

BLU-554 Chemical Structure

BLU-554 Chemical Structure

CAS No. : 1707289-21-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 233 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg USD 990 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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View All FGFR Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.

IC50 & Target[1]

FGFR4

 

In Vitro

Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (49.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9866 mL 9.9329 mL 19.8657 mL
5 mM 0.3973 mL 1.9866 mL 3.9731 mL
10 mM 0.1987 mL 0.9933 mL 1.9866 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

503.38

Formula

C₂₄H₂₄Cl₂N₄O₄

CAS No.

1707289-21-1

SMILES

C=CC(N[[email protected]@H]1[[email protected]](NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)COCC1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.84%

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Product Name:
BLU-554
Cat. No.:
HY-100492
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BLU-554

Cat. No.: HY-100492