Cat. No.: HY-W001925

7-Methoxy-1-tetralone

Customer Review

Based on 1 Customer Validation

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index.

For research use only. We do not sell to patients.

Purity: 99.70%
CAS No.: 6836-19-7
Formula: C₁₁H₁₂O₂
Molecular Weight:176.21

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

7-Methoxy-1-tetralone Chemical Structure

CAS No.: 6836-19-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NF-κB Isoforms :

All Akt Isoforms :

All MMP Isoforms :

In Vitro

7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) inhibits proliferative activity of LO2 and HepG2 cells^[1].
7-Methoxy-1-tetralone (40 μM, 100 μM, and 250 μM; 48 h) induces HepG2 cell apoptosis, and decreases the protein expression levels of c-Met, p-AKT, AKT, NF-κB, MMP2, and MMP9 in cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

40 μM, 100 μM, and 250 μM
Incubation Time:

48 h
Result:

Decreased the protein expression levels of c-Met, p-AKT, NF-κB, MMP2, and MMP9.

Cell Proliferation Assay^[1]

Cell Line:

LO2 and HepG2 cells
Concentration:

31.25 μM, 62.5 μM, 125 μM, 250 μM, 500 μM, and 1000 μM
Incubation Time:

24 h, 48 h, and 72 h
Result:

Exhibited anti-proliferative activity of MT on LO2 and HepG2 cells.

In Vivo

7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d; ip; 19 doses in total) inhibits tumor growth in subcutaneously implanted tumor model with HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice (5-week-old) with subcutaneously implanted HepG2 cells^[1]
Dosage:

80, 120, or 160 mg/kg/d
Administration:

Intraperitoneal injection; sacrificed after 19 days
Result:

Resulted the tumor inhibition rates of 40.57% (80 mg/kg), 51.43% (120 mg/kg), 79.43% (160 mg/kg), respectively.

Chemical Information

CAS No. 6836-19-7
Appearance Solid
Molecular Weight 176.21
Formula C₁₁H₁₂O₂
Color Off-white to yellow
SMILES

O=C(CCC1)C2=C1C=CC(OC)=C2
Structure Classification
- Phenols
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (567.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.6750 mL

28.3752 mL

56.7505 mL

5 mM

1.1350 mL

5.6750 mL

11.3501 mL

10 mM

0.5675 mL

2.8375 mL

5.6750 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (14.19 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.6750 mL	28.3752 mL	56.7505 mL	141.8762 mL
	5 mM	1.1350 mL	5.6750 mL	11.3501 mL	28.3752 mL
	10 mM	0.5675 mL	2.8375 mL	5.6750 mL	14.1876 mL
	15 mM	0.3783 mL	1.8917 mL	3.7834 mL	9.4584 mL
	20 mM	0.2838 mL	1.4188 mL	2.8375 mL	7.0938 mL
	25 mM	0.2270 mL	1.1350 mL	2.2700 mL	5.6750 mL
	30 mM	0.1892 mL	0.9458 mL	1.8917 mL	4.7292 mL
	40 mM	0.1419 mL	0.7094 mL	1.4188 mL	3.5469 mL
	50 mM	0.1135 mL	0.5675 mL	1.1350 mL	2.8375 mL
	60 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	80 mM	0.0709 mL	0.3547 mL	0.7094 mL	1.7735 mL
	100 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.4188 mL

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7-Methoxy-1-tetralone

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

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PI3K/Akt/mTOR Compound Library

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All NF-κB Isoforms

All Akt Isoforms

All MMP Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

7-Methoxy-1-tetralone Related Classifications

HY-W001925 Related Classifications