Zorifertinib hydrochloride
Based on 7 publication(s) in Google Scholar
Zorifertinib (AZD3759) hydrochloride is a potent, orally active, BBB-penetrant, EGFR inhibitor (IC50s: 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively). Zorifertinib hydrochloride induces cancer cell apoptosis. Zorifertinib hydrochloride has antitumor activity, and can be used for NSCLC, HCC etc. research.
For research use only. We do not sell to patients.
- CAS No.: 1626387-81-2
- Formula: C22H24Cl2FN5O3
- Molecular Weight:496.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Zorifertinib hydrochloride
More- Nat Commun. 2025 Dec 17;16(1):11181. [Abstract]
- Sci Adv. Sci Adv. 2024 Jun 21;10(25):eadk2299. d [Abstract]
- RSC Adv. 2022 Jul 21;12(32):20991-21003. [Abstract]
- J Neurochem. 2024 Mar;168(3):205-223. [Abstract]
- J Pharm Biomed Anal. 2022 Mar 20:211:114626. [Abstract]
- bioRxiv. 2023 Jun 9:2023.06.07.544128. [Abstract]
- Patent. US20220177473A1.
All EGFR Isoforms
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Biological Activity
Chemical Information
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CAS No. 1626387-81-2
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Molecular Weight 496.36
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Formula C22H24Cl2FN5O3
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SMILES
ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F.Cl
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Synonyms
AZD3759 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Commun
Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells. [Abstract]2025 Dec 17;16(1):11181. PMID: 41407982 -
Sci Adv
In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss. [Abstract]Sci Adv. 2024 Jun 21;10(25):eadk2299. d PMID: 38896614 -
RSC Adv
Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry. [Abstract]2022 Jul 21;12(32):20991-21003. PMID: 35919181 -
J Neurochem
Molecular prognostic of nine parthanatos death-related genes in glioma, particularly in COL8A1 identification. [Abstract]2024 Mar;168(3):205-223. PMID: 38225203 -
J Pharm Biomed Anal
2022 Mar 20:211:114626. PMID: 35123331 -
bioRxiv
In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss. [Abstract]2023 Jun 9:2023.06.07.544128. PMID: 37333346 -
Purity & Documentation
References
[1]. Zeng Q, et al. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15. [Content Brief]
[2]. Chao D, et al. AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop. Biochem Biophys Res Commun. 2019 Feb 5;509(2):535-540. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zorifertinib hydrochloride Related Classifications
HY-18750A Related Classifications
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