2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-92

Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research.

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Antitumor agent-92

Antitumor agent-92 Chemical Structure

CAS No. : 2922842-01-9

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Antitumor agent-92 Related Antibodies

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Description

Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research[1].

Cellular Effect
Cell Line Type Value Description References
Hep 3B2 IC50
3.9 μM
Compound: 11c
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36745506]
HepG2 IC50
7.6 μM
Compound: 11c
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36745506]
SMMC-7721 IC50
3.1 μM
Compound: 11c
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36745506]
In Vitro

Antitumor agent-92 (compound 11c; 2-8 μM; 48 h) induces apoptosis in HepG2 and SMMC-7721 cells, especially at high concentrations[1].
Antitumor agent-92 (2-8 μM; 48 h) can induce the G0/G1 cycle arrest in HepG2 and SMMC-7721 cells[1].
Antitumor agent-92 (2-8 μM; 48 h) upregulates P21 and downregulates Cdc2 p34 and CDK4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-92 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.

Western Blot Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.
Molecular Weight

611.68

Formula

C33H41NO10
CAS No.
SMILES

COC1=CC=C(C=C1)C2=C(C(C3=C(C=C(C(C/C=C(C)\C)=C3O2)OCCN4CCCC4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O)O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-92 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-922922842-01-9Antitumor agent92Antitumor agent 92ApoptosisIcaritinG0/G1cell cycleHepG2SMMC-7721hepatocellular carcinoma (HCC)Inhibitorinhibitorinhibit

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