2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-92

Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research.

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Antitumor agent-92 Chemical Structure

Antitumor agent-92 Chemical Structure

CAS No. : 2922842-01-9

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Antitumor agent-92 Related Antibodies

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Description

Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research[1].

In Vitro

Antitumor agent-92 (compound 11c; 2-8 μM; 48 h) induces apoptosis in HepG2 and SMMC-7721 cells, especially at high concentrations[1].
Antitumor agent-92 (2-8 μM; 48 h) can induce the G0/G1 cycle arrest in HepG2 and SMMC-7721 cells[1].
Antitumor agent-92 (2-8 μM; 48 h) upregulates P21 and downregulates Cdc2 p34 and CDK4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-92 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.

Western Blot Analysis[1]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.
Molecular Weight

611.68

Formula

C33H41NO10
CAS No.
SMILES

COC1=CC=C(C=C1)C2=C(C(C3=C(C=C(C(C/C=C(C)\C)=C3O2)OCCN4CCCC4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O)O)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Antitumor agent-92 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-922922842-01-9Antitumor agent92Antitumor agent 92ApoptosisIcaritinG0/G1cell cycleHepG2SMMC-7721hepatocellular carcinoma (HCC)Inhibitorinhibitorinhibit

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