1. Immunology/Inflammation
  2. Thrombopoietin Receptor
  3. Eltrombopag

Eltrombopag (Synonyms: SB-497115)

Cat. No.: HY-15306 Purity: 99.82%
Handling Instructions

Eltrombopag (SB-497115) is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.

For research use only. We do not sell to patients.

Eltrombopag Chemical Structure

Eltrombopag Chemical Structure

CAS No. : 496775-61-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 105 In-stock
Estimated Time of Arrival: December 31
10 mg USD 95 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg USD 245 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Eltrombopag:

Top Publications Citing Use of Products

    Eltrombopag purchased from MCE. Usage Cited in: Blood Adv. 2017 Feb 28;1(7):468-476.

    STAT5 phosphorylation in UT-7/TPO cells stimulated for 15 to 360 minutes with rhTPO (100 ng/mL), TA-316 (100 ng/mL), Eltrombopag (1000 ng/mL), or DMSO (vehicle) are evaluated using BD Phosflow (STAT5, pY694).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Eltrombopag (SB-497115) is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.

    Clinical Trial
    Molecular Weight

    442.47

    Formula

    C₂₅H₂₂N₄O₄

    CAS No.

    496775-61-2

    SMILES

    O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (75.33 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2600 mL 11.3002 mL 22.6004 mL
    5 mM 0.4520 mL 2.2600 mL 4.5201 mL
    10 mM 0.2260 mL 1.1300 mL 2.2600 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1 mg/mL (2.26 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    EltrombopagSB-497115SB497115SB 497115Thrombopoietin ReceptorInhibitorinhibitorinhibit

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    Product name:
    Eltrombopag
    Cat. No.:
    HY-15306
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