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Cat. No.: HY-141813

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Autophagy-IN-C1

Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

For research use only. We do not sell to patients.

CAS No.: 1494665-31-4
Formula: C₂₉H₂₈F₆N₄O₂
Molecular Weight:578.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Autophagy-IN-C1 Chemical Structure

CAS No.: 1494665-31-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

Cellular Effect

Cell Line	Type	Value	Description	References
HCA1	IC₅₀	0.23 μM Compound: C1	Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Hep 3B2	IC₅₀	0.27 μM Compound: C1	Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay	[PMID: 34558909]
HepG2	IC₅₀	0.69 μM Compound: C1	Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Mahlavu	IC₅₀	0.13 μM Compound: C1	Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay	[PMID: 34558909]

Chemical Information

CAS No. 1494665-31-4
Molecular Weight 578.55
Formula C₂₉H₂₈F₆N₄O₂
SMILES

O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N[C@H]([C@@]2([H])[N@](CC3C=C)CC[C@H]3C2)C4=C(C=C(OC)C=C5)C5=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin PR, et al. Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy. J Med Chem. 2021 Oct 14;64(19):14513-14525. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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