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Cat. No.: HY-173387

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4F-Docetaxel

(Synonyms: 4FDT)

4F-Docetaxel (4FDT) is a fluorinated docetaxel analog. 4F-Docetaxel has anti-hepatoma activity and can be used for research of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

CAS No.: 912272-09-4
Formula: C₄₃H₄₉F₄NO₁₄
Molecular Weight:879.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

4F-Docetaxel Chemical Structure

CAS No.: 912272-09-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

4F-Docetaxel (4FDT) is a fluorinated docetaxel analog. 4F-Docetaxel has anti-hepatoma activity and can be used for research of hepatocellular carcinoma (HCC)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCD-18Co	IC₅₀	17.13 μM Compound: 4FDT	Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32203786]
HCT-116	IC₅₀	0.1 nM Compound: 4FDT	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32203786]
HCT-116	IC₅₀	0.1 x 10^-3 μM Compound: 4FDT	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32203786]
HEK293	IC₅₀	0.36 μM Compound: 4FDT	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32203786]
SK-OV-3	IC₅₀	3.4 x 10^-2 μM Compound: 14f	Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 18524425]
SK-OV-3	IC₅₀	34 nM Compound: 14f	Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay	[PMID: 18524425]
SW-620	IC₅₀	0.28 μM Compound: 4FDT	Cytotoxicity against human SW-620 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human SW-620 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 32203786]

In Vitro

4F-Docetaxel shows cytotoxic activity against several tumor cell lines, with IC₅₀s of 0.049 μM (95-D), 0.070 μM (SKOV3), 0.958 μM (HCT-116), 0.021 μM (HepG2), 0.022 μM (Bel-7402), 0.014 μM (SMMC-7721), 0.011 μM (SGC-7901), 0.043 μM (MDA-MB-231), 0.017 μM (A2780), 0.012 μM (KB), 0.006 μM (HL-60), 6.6 μM (U2OS), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 912272-09-4
Molecular Weight 879.84
Formula C₄₃H₄₉F₄NO₁₄
SMILES

CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)O)=C([C@H](C4)OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C(F)(F)F)=O)=O)C)C)O)OC(C6=CC(F)=CC=C6)=O)=O
Synonyms

4FDT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hao YP, et al. Novel fluorinated docetaxel analog for anti-hepatoma: Molecular docking and biological evaluation. Eur J Pharm Sci. 2016 Jun 10;88:274-81. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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