HSP90-IN-10
HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2881071-86-7
- Formula: C30H26FN3O6
- Molecular Weight:543.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCC1954 | IC50 |
6 μM
Compound: 16s
|
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay
|
[PMID: 34844036] |
| HCC1954 | IC50 |
6 μM
Compound: 16s
|
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay
Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay
|
[PMID: 34844036] |
| MCF-10A | IC50 |
>30 μM
Compound: 16s
|
Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay
|
[PMID: 34844036] |
| MCF7 | IC50 |
6.2 μM
Compound: 16s
|
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
|
[PMID: 34844036] |
| MDA-MB-231 | IC50 |
>25 μM
Compound: 16s
|
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
|
[PMID: 34844036] |
Chemical Information
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CAS No. 2881071-86-7
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Molecular Weight 543.54
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Formula C30H26FN3O6
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SMILES
COC1=CC(C2=C3C(CC(C)(C/C3=N\OC(C4=CC(NC(C5=CC(F)=CC=C5)=O)=CC=C4)=O)C)=NO2)=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)