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Art. -Nr.: HY-144724

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HSP90-IN-10

HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC₅₀ value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis.

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CAS. Nr.: 2881071-86-7
Formel: C₃₀H₂₆FN₃O₆
Molecular Weight:543.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HSP90-IN-10 Chemical Structure

CAS. Nr.: 2881071-86-7

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Biologische Aktivität

Beschreibung

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCC1954	IC₅₀	6 μM Compound: 16s	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by MTT assay	[PMID: 34844036]
HCC1954	IC₅₀	6 μM Compound: 16s	Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay Antiproliferative activity against human HCC1954 cells measured after 72 hrs by SRB assay	[PMID: 34844036]
MCF-10A	IC₅₀	>30 μM Compound: 16s	Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells measured after 72 hrs by MTT assay	[PMID: 34844036]
MCF7	IC₅₀	6.2 μM Compound: 16s	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 34844036]
MDA-MB-231	IC₅₀	>25 μM Compound: 16s	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay	[PMID: 34844036]

Chemical Information

CAS. Nr. 2881071-86-7
Molecular Weight 543.54
Formel C₃₀H₂₆FN₃O₆
SMILES

COC1=CC(C2=C3C(CC(C)(C/C3=N\OC(C4=CC(NC(C5=CC(F)=CC=C5)=O)=CC=C4)=O)C)=NO2)=CC=C1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Piven YA, et al. Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells. Bioorg Med Chem. 2022 Jan 1;53:116521. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HSP90-IN-10

Alle HSP Isoform-spezifische Produkte anzeigen

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HSP90-IN-10 Related Classifications

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