Tubulin polymerization-IN-45
Tubulin polymerization-IN-45, a tubulin-targeting agent, is a tubulin polymerization inhibitor. Tubulin polymerization-IN-45 binds to the colchicine site of tubulin. Tubulin polymerization-IN-45 induces apoptotic cell death in hepatocellular cancer (HCC) cells.
For research use only. We do not sell to patients.
- Formula: C20H18N4O3
- Molecular Weight:362.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tubulin polymerization-IN-45 (compound 18) shows potent activity against the hepatocellular cancer (HCC) cell lines, with IC50 values in the range 0.6-2.9 μM. Tubulin polymerization-IN-45 also exhibits moderate inhibitory activity against tubulin polymerization (IC50= 19 μM). Tubulin polymerization-IN-45 causes cell cycle arrest at the G2/M phase in both Huh7 and Mahlavu cells and induces apoptotic cell death in HCC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 362.38
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Formula C20H18N4O3
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SMILES
O=C(NC1=CC(OC)=CC=C1OC)C2=NNC(C3=CNC4=CC=CC=C43)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-45 Related Classifications
HY-155139 Related Classifications
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