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LEI110 

Cat. No.: HY-125254
Handling Instructions

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells.

For research use only. We do not sell to patients.

LEI110 Chemical Structure

LEI110 Chemical Structure

CAS No. : 2313525-90-3

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Description

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells[1].

IC50 & Target

pIC50: 7.0 (PLA2G16), 6.8 (HRASLS2), 6.8 (RARRES3), and 7.6 (iNAT)[1]

Molecular Weight

456.46

Formula

C25H23F3N2O3

CAS No.
SMILES

O=C(NCCC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(CCCC3=CC=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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