1. Anti-infection
  2. SARS-CoV
  3. Silymarin

Silymarin 

Cat. No.: HY-N7073 Purity: ≥80.0%
Handling Instructions

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin, a food-derived antiviral molecule, is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research.

For research use only. We do not sell to patients.

Silymarin Chemical Structure

Silymarin Chemical Structure

CAS No. : 65666-07-1

Size Price Stock Quantity
250 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 75 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Silymarin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin, a food-derived antiviral molecule, is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4].

In Vitro

Silymarin (0-120 µg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 µg/ml silymarin, 71.5% at 40 µg/ml, 59.8% at 60 µg/ml, 44.5% at 80 µg/ml, 35.3% at 100 µg/ml and 33.9% at 120 µg/ml[1].
Silymarin (40-80 µg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 µg/ml and 21.7% at 80 µg/ml,respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: AGS cells
Concentration: 20 µg/ml, 40 µg/ml, 80 µg/ml, 100 µg/ml and 120 µg/ml
Incubation Time: 24 hours
Result: Indicated a significant concentration-dependent inhibitory effect on AGS cells starting at 20 µg/ml.
In Vivo

Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED50) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥80.0%

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Silymarin
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