2. Anti-infection
  3. SARS-CoV
  4. Silymarin

Silymarin 

Cat. No.: HY-N7073 Purity: ≥80.0%
COA Handling Instructions

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research.

For research use only. We do not sell to patients.

Silymarin Chemical Structure

Silymarin Chemical Structure

CAS No. : 65666-07-1

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Based on 3 publication(s) in Google Scholar

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Description

Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4].

In Vitro

Silymarin (0-120 µg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 µg/ml silymarin, 71.5% at 40 µg/ml, 59.8% at 60 µg/ml, 44.5% at 80 µg/ml, 35.3% at 100 µg/ml and 33.9% at 120 µg/ml[1].
Silymarin (40-80 µg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 µg/ml and 21.7% at 80 µg/ml,respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: AGS cells
Concentration: 20 µg/ml, 40 µg/ml, 80 µg/ml, 100 µg/ml and 120 µg/ml
Incubation Time: 24 hours
Result: Indicated a significant concentration-dependent inhibitory effect on AGS cells starting at 20 µg/ml.
In Vivo

Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED50) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Appearance

Solid

CAS No.
SMILES

[Silymarin]
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥80.0%

COA (243 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Silymarin65666-07-1SARS-CoVSARS coronavirusMilkthistleproliferationangiogenesisinsulinresistancechemopreventive hepatocellularcarcinomaHCCInhibitorinhibitorinhibit

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