2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Anti-Mouse OX40L/CD134L Antibody (RM134L)

Anti-Mouse OX40L/CD134L Antibody (RM134L) 

製品番号: HY-P990175 純度: 95.00%
COA Technical Support

Anti-Mouse OX40L/CD134L Antibody (RM134L) is an anti-mouse OX40L/CD134L IgG2b monoclonal antibody. Anti-Mouse OX40L/CD134L Antibody (RM134L) reduces immune response by inhibiting the OX40/OX40L signaling pathway. Anti-Mouse OX40L/CD134L Antibody (RM134L) can inhibit plasma cell differentiation and antibody secretion. Anti-Mouse OX40L/CD134L Antibody (RM134L) can prolong the survival time of cell transplantation by inhibiting CD4+ T cells. Anti-Mouse OX40L/CD134L Antibody (RM134L) can be used for researches on inflammation and cancer such as graft versus host disease (GVHD), allergic reaction, lupus nephritis and hepatocellular carcinoma (HCC).

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Anti-Mouse OX40L/CD134L Antibody (RM134L)

Anti-Mouse OX40L/CD134L Antibody (RM134L) 構造式

容量 価格（税別） 在庫状況 数量
1 mg $200 在庫あり
5 mg $650 在庫あり
10 mg $1050 在庫あり
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製品説明

Anti-Mouse OX40L/CD134L Antibody (RM134L) is an anti-mouse OX40L/CD134L IgG2b monoclonal antibody. Anti-Mouse OX40L/CD134L Antibody (RM134L) reduces immune response by inhibiting the OX40/OX40L signaling pathway. Anti-Mouse OX40L/CD134L Antibody (RM134L) can inhibit plasma cell differentiation and antibody secretion. Anti-Mouse OX40L/CD134L Antibody (RM134L) can prolong the survival time of cell transplantation by inhibiting CD4+ T cells. Anti-Mouse OX40L/CD134L Antibody (RM134L) can be used for researches on inflammation and cancer such as graft versus host disease (GVHD), allergic reaction, lupus nephritis and hepatocellular carcinoma (HCC)[1][2][3][4].

Isotype

Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

OX40L/CD134L
体外実験

Anti-Mouse OX40L/CD134L Antibody (RM134L) (5 μg/mL) significantly inhibits the activation effect of tumor-associated macrophages (TAMs) on CD8+ T cells[3].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (1-100 μg/mL, 3 days) dose dependently inhibits Th1 and Tfh cells differentiation and promotes Treg cells differentiation[4].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (1-100 μg/mL, 72 h) inhibits the differentiation of plasma derived cells and the secretion of antibodies (IgG2b, IgG3, IgA, IgM), downregulates the expression of BLIMP1 and XBP1, and upregulates the expression of SPIB in B cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse OX40L/CD134L Antibody (RM134L) 関連抗体

Western Blot Analysis[4]

Cell Line: B cells
Concentration: 1, 10 and 100 μg/mL
Incubation Time: 72 h
Result: Reduced the level of BLIMP1 and XBP1 and increased the level of SPIB.
体内実験

Anti-Mouse OX40L/CD134L Antibody (RM134L) (0.5 mg, i.p., on day 0, 2, 4 and 8 for early stage, on day 21, 23, 25 and 29 for late stage) delays antibody production combined with CD40L mAb (HY-P990134) and CTLA4Ig (HY-108829) in female BALB/c mice with a Phl p 5 induced grass pollen allergy model[1].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (200 μg, i.p., once daily until day 5, then three times a week until day 28) significantly prolongs survival period in B10.BR/SgSnJ (H2k) mice with a graft versus host disease (GVHD) model[2].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (250 μg, i.p., once every 3 days, on day -2 until the endpoint) significantly reverses the anti-tumor effect of C12-iE-DAP in C57BL/6 mice bearing Hepa 1-6, B16F10 or MC38 tumors[3].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (100 μg, i.p., twice weekly, for 10 weeks) relieves lupus nephritis in female MRL/Lpr mice with a spontaneous lupus model[4].
Anti-Mouse OX40L/CD134L Antibody (RM134L) (100 μg, i.p., once daily, for 3 weeks) reduces autoimmune response in female C57BL/6J mice injected with keyhole limpet hemocyanin (KLH)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Phl p 5 (5 μg) injected female BALB/c mice (6-12 weeks)[1]
Dosage: 0.5 mg, combined with CD40L mAb (1 mg) and CTLA4Ig (0.5 mg)
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 8 for early stage, on day 21, 23, 25 and 29 for late stage
Result: Delayed antibody production.
Had no significant effect on the humoral and effector cell levels of allergic reactions, only slightly inhibiting T cell responses when OX40L mAb is used alone.
Animal Model: T cells injected B10.BR/SgSnJ (H2k) mice (8-10 weeks)[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), once daily until day 5, then three times a week until day 28
Result: Increased the long-term survival rate from 0 % to 35 %.
Inhibited CD4+ T cell-mediated GVHD.
Animal Model: 5×106 Hepa 1-6 or B16F10 or 1×106 MC38 cells injected C57BL/6 mice (6-8 weeks)[3]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days, on day -2 until the endpoint
Result: Weakened tumor growth inhibition.
Animal Model: Female MRL/Lpr mice (11 weeks)[4]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), twice weekly, for 10 weeks
Result: Reduced anti dsDNA antibodies and proteinuria.
Reduced renal IgG and C3 deposition.
Reduced the proportion of Th1 and Tfh cells in the spleen.
Animal Model: KLH (0.5 mg/mL) injected female C57BL/6J mice (8 weeks)[4]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 weeks
Result: Reduced serum IgG1, IgG2b, IgG3, IgA, IgM levels.
Reduced the number and area of hair growth centers (GC).
Inhibited the proportion of plasma derived cells and Tfh cells in the spleen and lymph nodes.
Gene ID

22164  [NCBI]

Accession
Application

in vivo blocking of OX40/OX40L signaling; in vitro OX40L neutralization
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse OX40L/CD134L Antibody (RM134L)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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Anti-Mouse OX40L/CD134L Antibody (RM134L) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse OX40L/CD134L Antibody (RM134L)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOX40L/CD134LCD4T cellsplasma cellGVHDallergiclupus nephritisHepa 1-6B16F10MC38Inhibitorinhibitorinhibit

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製品名:
Anti-Mouse OX40L/CD134L Antibody (RM134L)
製品番号:
HY-P990175
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