Abatacept (Synonyms: CTLA4lg; BMS-188667)

Name: Abatacept
Brand: MedChemExpress
SKU: HY-108829
Rating: 4.5 (1 reviews)

Cat. No.: HY-108829 Purity: ≥99.0%: Data Sheet
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Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases.

For research use only. We do not sell to patients.

CAS No. : 332348-12-6

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Based on 1 publication(s) in Google Scholar

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Abatacept (powder) In-stock

1 Publications Citing Use of MCE Abatacept

•Cell Rep. 2024 Aug 22;43(9):114664. [Abstract]

In Vivo Efficacy Study

: Abatacept purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Aug 22;43(9):114664. [Abstract]; CTLA4-Ig (0.25 mg; ip). Kaplan-Meier curve with log-rank test for graft survival.

: Abatacept purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Aug 22;43(9):114664. [Abstract]; CTLA4-Ig (0.25 mg; ip). Leukocytes infiltrated in native hearts and allografts of CTLA4-Ig plus CD40-TRAF6i-NB-treated mice 100 days post-transplantation.

: Abatacept purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Aug 22;43(9):114664. [Abstract]; CTLA4-Ig (0.25 mg; ip). Immune cell subsets in allografts of CTLA4-Ig plus CD40-TRAF6i-NB-treated recipient mice 100 days post-transplantation.

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Description

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains)^[1]. Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases^[1]^[2]^[3].

In Vivo

Abatacept reduces paw edema, and the SC Multiple-dose group shows significantly greater (t_obs = 2.50) paw edema reduction compared with the IV dose group^[2].
Abatacept exhibits linear PK across the studied doses. The NCA clearance (CL) is 20.8 mL/day/kg, volume (V_ss) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%^[2].
Abatacept (oral; 10 mg/kg; every 2 days) reduces the proportion of activated T cells (CD44highCD62L–) and inhibits the up-regulation of ICOS and CD71 in homozygous DO11.10 RAG-2^–/–BALB/c (H-2d/d) mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Lewis rats (6-9 weeks old) with weights of 150-175 g^[2]
Dosage:	10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29
Administration:	IV or SC
Result:	Reduced paw edema, and the SC Multiple-dose group showed significantly greater (t_obs = 2.50) paw edema reduction compared with the IV dose group.

Animal Model:	Male Lewis rats (6-9 weeks old) with weights of 150-175 g^[2]
Dosage:	10 mg/kg (IV), 20 mg/kg (SC single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29 (Pharmacokinetic Study)
Administration:	IV or SC
Result:	The NCA clearance (CL) is 20.8 mL/day/kg, volume (V_ss) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7%.

Clinical Trial

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

84.4 kDa

CAS No.

332348-12-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Abatacept]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

[CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CD152)]2-IGHG1 Fc (Fragment constant)

Biological Activity

Flow cytometry analysis of CD80 overexpression CHOK1 cells labelling CD80 with Abatacept at 20nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (261 KB) SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Kiykim A, et al. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. J Allergy Clin Immunol Pract. 2019 Jun 22. [Content Brief]

[2]. Lon HK, et al. Modeling pharmacokinetics/pharmacodynamics of abatacept and disease progression in collagen-induced arthritic rats: a population approach. J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):701-12. [Content Brief]

[3]. Patakas A, et al. Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells. Arthritis Rheumatol. 2016 Mar;68(3):627-38. [Content Brief]

Abatacept Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abatacept332348-12-6CTLA4lg BMS-188667BMS188667BMS 188667BMS-188667CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152CD28B7 ligands CD80/CD86Inhibitorinhibitorinhibit

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Abatacept (Synonyms: CTLA4lg; BMS-188667)

Customer Review

Other Forms of Abatacept:

Abatacept Related Antibodies

1 Publications Citing Use of MCE Abatacept

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References

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Abatacept Related Classifications

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The molarity calculator equation

The dilution calculator equation

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