1. Apoptosis
  2. TNF Receptor
  3. Etanercept

Etanercept 

Cat. No.: HY-108847 Purity: >96.0%
Handling Instructions

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

For research use only. We do not sell to patients.

Etanercept Chemical Structure

Etanercept Chemical Structure

CAS No. : 185243-69-0

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Estimated Time of Arrival: December 31
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Description

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

IC50 & Target[1][2]

TNF-α

 

TNF-β

 

In Vivo

Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
Dosage: 10 mg/kg
Administration: S.c.; every 3 days for 3 weeks
Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
Clinical Trial
CAS No.

185243-69-0

SMILES

[Etanercept]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

Purity: >96.0%

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Keywords:

EtanerceptTNF ReceptorTumor Necrosis Factor ReceptorTNFRrheumatoidarthritissolublereceptorcellsurfaceproinflammatorycytokineInhibitorinhibitorinhibit

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Etanercept
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