2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Etanercept

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

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Etanercept Chemical Structure

Etanercept Chemical Structure

CAS No. : 185243-69-0

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Based on 4 publication(s) in Google Scholar

Etanercept Related Antibodies

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Description

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

IC50 & Target[1][2]

Fas

 

In Vivo

Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
Dosage: 10 mg/kg
Administration: S.c.; every 3 days for 3 weeks
Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
Clinical Trial
Molecular Weight

150000 (Average)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Etanercept]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.20%

COA (231 KB)

Handling Instructions (2659 KB)
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Etanercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etanercept185243-69-0TNF ReceptorBacterialTumor Necrosis Factor ReceptorTNFRrheumatoidarthritissolublereceptorcellsurfaceproinflammatorycytokineInhibitorinhibitorinhibit

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