2. Apoptosis Anti-infection
  3. TNF Receptor Bacterial
  4. Etanercept

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

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CAS No. : 185243-69-0

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Customer Review

Based on 15 publication(s) in Google Scholar

Etanercept Featured Recommendations:

Etanercept Related Antibodies

Top Publications Citing Use of Products

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Evaluation of arthritis scores for non-immunized (NI) mice or CIA mice in different treatment groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Representative micro-CT images of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Images of H&E and SafO-FG staining of the paw sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Measurement of BS/BV, and quantification of synovial inflammation and bone erosion on H&E-stained sections, as well as cartilage erosion on SafO-FG-stained sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Immunofluorescence staining of FOXK1, STAT1, STAT2, IL-6, IL-1β and MMP3 on sections of paws of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    View All TNF Receptor Isoform Specific Products:

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    TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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    Description

    Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

    IC50 & Target[1][2]

    Fas

     

    In Vivo

    Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
    Dosage: 10 mg/kg
    Administration: S.c.; every 3 days for 3 weeks
    Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
    Clinical Trial
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    102.5 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Etanercept]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • [TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)
    Biological Activity
    • Immobilized TNF-alpha/TNFSF2 Protein, Human (His, HY-P7416) can bind Etanercept. The EC50 for this effect is 9.44 ng/mL.
    Purity & Documentation

    Purity: 99.20%

    SDS (419 KB)

    COA (231 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Etanercept Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Etanercept185243-69-0TNF ReceptorBacterialTumor Necrosis Factor ReceptorTNFRrheumatoidarthritissolublereceptorcellsurfaceproinflammatorycytokineInhibitorinhibitorinhibit

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