1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA

Bucladesine sodium salt (Synonyms: Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP)

Cat. No.: HY-B0764 Purity: 99.33%
Data Sheet SDS Handling Instructions

Bucladesine is a membrane permeable selective activator of PKA.

For research use only. We do not sell to patients.
Bucladesine sodium salt Chemical Structure

Bucladesine sodium salt Chemical Structure

CAS No. : 16980-89-5

Size Price Stock Quantity
10 mM * 1 mL in Water $72 In-stock
50 mg $65 In-stock
100 mg $80 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Bucladesine sodium salt:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Bucladesine is a membrane permeable selective activator of PKA. Target: PKA Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats [1]. Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine [2]. Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin [3]. Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice [4].

References
Molecular Weight

491.37

Formula

C₁₈H₂₃N₅NaO₈P

CAS No.

16980-89-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 42 mg/mL; DMSO: < 7 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Bucladesine sodium salt
Cat. No.:
HY-B0764
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