1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. PKA
    Phosphodiesterase (PDE)
  3. Bucladesine sodium salt

Bucladesine sodium salt (Synonyms: Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP)

Cat. No.: HY-B0764 Purity: 99.71%
Handling Instructions

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP) is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine sodium salt acts as a phosphodiesterase (PDE) inhibitor.

For research use only. We do not sell to patients.

Bucladesine sodium salt Chemical Structure

Bucladesine sodium salt Chemical Structure

CAS No. : 16980-89-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 86 In-stock
Estimated Time of Arrival: December 31
50 mg USD 78 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Bucladesine sodium salt (Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP) is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine sodium salt acts as a phosphodiesterase (PDE) inhibitor.

IC50 & Target[5]

PKA

 

PDE

 

Molecular Weight

491.37

Formula

C₁₈H₂₃N₅NaO₈P

CAS No.

16980-89-5

SMILES

O=C(CCC)O[[email protected]]1[[email protected]](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[[email protected]@](CO4)([H])[[email protected]@]1([H])OP4([O-])=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (305.27 mM; Need ultrasonic)

H2O : ≥ 42 mg/mL (85.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0351 mL 10.1756 mL 20.3513 mL
5 mM 0.4070 mL 2.0351 mL 4.0703 mL
10 mM 0.2035 mL 1.0176 mL 2.0351 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.71%

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Keywords:

BucladesineDibutyryl-cAMPDC2797Sodium dibutyryl cAMPDC 2797DC-2797PKAPhosphodiesterase (PDE)Protein kinase AInhibitorinhibitorinhibit

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Bucladesine sodium salt
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HY-B0764
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