1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA

Bucladesine sodium salt (Synonyms: Dibutyryl-cAMP sodium salt; DC2797; Sodium dibutyryl cAMP)

Cat. No.: HY-B0764 Purity: 99.33%
Handling Instructions

Bucladesine is a membrane permeable selective activator of PKA.

For research use only. We do not sell to patients.
Bucladesine sodium salt Chemical Structure

Bucladesine sodium salt Chemical Structure

CAS No. : 16980-89-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 86 In-stock
50 mg USD 78 In-stock
100 mg USD 96 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Bucladesine sodium salt:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Bucladesine is a membrane permeable selective activator of PKA. Target: PKA Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats [1]. Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine [2]. Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin [3]. Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice [4].

Molecular Weight







O=C(CCC)O[[email protected]]1[[email protected]](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[[email protected]@](CO4)([H])[[email protected]@]1([H])OP4([O-])=O.[Na+]

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 42 mg/mL; DMSO: < 7 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.33%

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